Isopropyl-(2-methyl-5-phenyl-2H-pyrazol-3-yl)-amine | 653574-52-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: Isopropyl-(2-methyl-5-phenyl-2H-pyrazol-3-yl)-amine
• 英文别名: 1H-Pyrazol-5-amine, 1-methyl-N-(1-methylethyl)-3-phenyl-；2-methyl-5-phenyl-N-propan-2-ylpyrazol-3-amine
• CAS: 653574-52-8
• 化学式: C₁₃H₁₇N₃
• 分子量: 215.298
• InChiKey: XEGOKPFWSBIHQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  29.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  Isopropyl-[3-methyl-5-phenyl-3,6-dihydro-[1,3,4]thiadiazin-(2Z)-ylidene]-amine 在 溶剂黄146 作用下， 反应 40.0h， 以81%的产率得到Isopropyl-(2-methyl-5-phenyl-2H-pyrazol-3-yl)-amine
  参考文献：
  名称：

  Synthesis and Reactivity of 3,4-Dimethyl-4H-1,3,4-thiadiazines

  摘要：

  3,4 二甲基-4H-1,3,4-噻二嗪是一种新型 8Ï 杂环系统，由 δ-卤酮与 1,2,4- 三烷基硫代氨基脲环化制备而成。产物脱硫后，通过价态异构化得到 5-亚氨基-1,2-二甲基吡唑，并转化为噻-Ï-高吡唑。

  DOI：

  10.1055/s-2003-43342

文献信息

• 2-AMINOTHIAZOLE-4-CARBOXYLIC AMIDES AS PROTEIN KINASE INHIBITORS
  申请人：Shipps, JR. Gerald W.

  公开号：US20100055090A1

  公开（公告）日：2010-03-04

  The present invention relates to novel Anilinopiperazine Derivatives of formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral disease, a fungal infection, or a disorder related to the activity of a protein kinase.
• Thiazole Derivatives as Protein Kinase Inhibitors
  申请人：Reddy Panduranga Adulla P.

  公开号：US20100331313A1

  公开（公告）日：2010-12-30

  The present invention relates to novel Thiazole Derivatives, compositions comprising the Thiazole Derivatives, and methods for using the Thiazole Derivatives for treating or preventing a proliferative disorder, an anti-proliferative disorder, inflammation, arthritis, a central nervous system disorder, a cardiovascular disease, alopecia, a neuronal disease, an ischemic injury, a viral infection, a fungal infection, or a disorder related to the activity of a protein kinase.
• US8227605B2
  申请人：——

  公开号：US8227605B2

  公开（公告）日：2012-07-24
• US8476278B2
  申请人：——

  公开号：US8476278B2

  公开（公告）日：2013-07-02