1-Heptadecanaminium, N,N,N-trimethyl-4-oxo-2-(1-oxotetradecyl)- | 185810-19-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Heptadecanaminium, N,N,N-trimethyl-4-oxo-2-(1-oxotetradecyl)-
• 英文别名: trimethyl-(4-oxo-2-tetradecanoylheptadecyl)azanium
• CAS: 185810-19-9
• 化学式: C34H68NO2+
• 分子量: 522.9
• InChiKey: NCZWQVUOHVLIJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.1
• 重原子数：
  37
• 可旋转键数：
  29
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] ALKYLATED NUCLEOSIDES, AND COMPOSITIONS AND METHODS THEREOF FOR NUCLEIC ACID DELIVERY<br/>[FR] NUCLÉOSIDES ALKYLÉS, COMPOSITIONS ET PROCÉDÉS ASSOCIÉS POUR L'ADMINISTRATION D'ACIDES NUCLÉIQUES
  申请人：MICROVASCULAR THERAPEUTICS LLC

  公开号：WO2021142059A1

  公开（公告）日：2021-07-15

  The invention provides novel compounds, compositions and formulations of liposomes, microbubbles and/or nanodroplets, and emulsions thereof, that are useful in delivery of various nucleic acids and genes (e.g., single stranded RNA, DNA, si-RNA and CRISPR constructs), as well as methods of preparation and use thereof including methods of imaging and gene delivery using ultrasound activation.

  本发明提供了新型化合物、组合物和脂质体、微气泡和/或纳米液滴以及它们的乳化物，这些化合物和组合物在传递各种核酸和基因（例如单链RNA、DNA、siRNA和CRISPR构建）方面是有用的，以及它们的制备和使用方法，包括使用超声激活的成像和基因传递方法。
• LIPOSOMAL COMPOSITIONS WITH LIGHT ILLUMINATION-INDUCED DRUG RELEASE
  申请人：Creighton University

  公开号：US20180243419A1

  公开（公告）日：2018-08-30

  Provided herein is a small molecule delivery system with illumination-induced small molecule release based on the binary combination of charged liposomes containing small molecules and oppositely charged conjugates of a peptide with a photosensitizer attached to one end of peptide chain, providing binding to liposomes and their permeabilization upon light illumination.

  这里提供了一种小分子递送系统，其基于带电脂质体和带有光敏剂的肽共轭物的二元组合，通过光照诱导小分子释放，提供与脂质体的结合和光照下的渗透性，从而实现小分子的释放。
• BRANCHED CATIONIC LIPIDS FOR NUCLEIC ACIDS DELIVERY SYSTEM
  申请人：Zhao Hong

  公开号：US20110305769A1

  公开（公告）日：2011-12-15

  The present invention is directed to cationic lipid for the delivery of oligonucleotides and methods of modulating an expression of a targeted gene using the nanoparticle compositions. In particular, the invention relates to cholesterol and its derivatives having multiple positively charged moieties via branching spacers, and nanoparticle compositions of oligonucleotides encapsulated in a mixture of a cationic lipid, a fusogenic lipid and a PEG lipid.

  本发明涉及用于递送寡核苷酸的阳离子脂质以及利用纳米粒子组合物调节靶向基因表达的方法。具体而言，本发明涉及通过分支间隔物具有多个带正电性的衍生物的胆固醇及其衍生物，以及封装在阳离子脂质、融合脂质和PEG脂质混合物中的寡核苷酸纳米粒子组合物。
• NANOPARTICLE COMPOSITIONS FOR NUCLEIC ACIDS DELIVERY SYSTEM
  申请人：Zhao Hong

  公开号：US20110111044A1

  公开（公告）日：2011-05-12

  The present invention is directed to nanoparticle compositions for the delivery of oligonucleotides and methods of modulating an expression of a targeted gene using the nanoparticle compositions. In particular, the invention relates to oligonucleotides encapsulated in a mixture of a cationic lipid, a fusogenic lipid and a PEG lipid.

  本发明涉及纳米颗粒组合物，用于输送寡核苷酸并使用该纳米颗粒组合物调节靶向基因的表达的方法。特别地，该发明涉及封装在阳离子脂质、融合脂质和PEG脂质混合物中的寡核苷酸。
• PROMPT NUCLEIC ACID DELIVERY CARRIER COMPOSITION
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：EP2140870A1

  公开（公告）日：2010-01-06

  An object of the present invention is to provide a carrier composition for nucleic acid delivery, which can efficiently deliver a nucleic acid into cells when a nucleic acid such as siRNA is administered to animal-derived cells or animals, and also has low toxicity and high safety, and a composition for nucleic acid delivery containing the carrier composition and nucleic acid. A carrier for nucleic acid delivery is prepared by using (A) a diacylphosphatidylcholine, (B) at least one member selected from the group consisting of cholesterol and derivatives thereof, and (C) an aliphatic primary amine. Also, a composition for nucleic acid delivery is prepared by mixing the carrier for nucleic acid delivery with a nucleic acid.

  本发明的目的是提供一种核酸递送载体组合物，当向动物源性细胞或动物递送 siRNA 等核酸时，该组合物能有效地将核酸递送到细胞中，而且毒性低、安全性高，还提供一种含有该载体组合物和核酸的核酸递送组合物。 一种用于递送核酸的载体是通过使用 (A) 二酰基磷脂酰胆碱、(B) 至少一种选自胆固醇及其衍生物组成的组的成员和 (C) 脂肪族伯胺来制备的。此外，还可通过将核酸载体与核酸混合制备核酸递送组合物。