2-(2'-methoxyphenyl)-3H-imidazo[4,5-b]pyridine | 53929-99-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(2'-methoxyphenyl)-3H-imidazo[4,5-b]pyridine
• 英文别名: 2-(2-methoxyphenyl)-1H-imidazo[4,5-b]pyridine
• CAS: 53929-99-0
• 化学式: C₁₃H₁₁N₃O
• mdl: MFCD22555726
• 分子量: 225.25
• InChiKey: PFHUJGAJIKIZHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.076
• 拓扑面积：
  50.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,3-二氨基吡啶 、 邻甲氧基苯甲醛 在 硝基苯 作用下， 生成 2-(2'-methoxyphenyl)-3H-imidazo[4,5-b]pyridine
  参考文献：
  名称：

  Hit generation and exploration: Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases

  摘要：

  A hit generation and exploration approach led to the discovery of 31 (2-(4-(6-chloro-2-(4-(dimethylamino) phenyl)-3H-imidazo[4,5-b] pyridin-7-yl) piperazin-1-yl)-N-(thiazol-2-yl) acetamide), a potent, novel inhibitor of Aurora-A, Aurora-B and Aurora-C kinases with IC50 values of 0.042, 0.198 and 0.227 mu M, respectively. Compound 31 inhibits cell proliferation and has good microsomal stability. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.09.076

文献信息

• US3985891A
  申请人：——

  公开号：US3985891A

  公开（公告）日：1976-10-12
• Hit generation and exploration: Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases
  作者：Vassilios Bavetsias、Chongbo Sun、Nathalie Bouloc、Jóhannes Reynisson、Paul Workman、Spiros Linardopoulos、Edward McDonald

  DOI：10.1016/j.bmcl.2007.09.076

  日期：2007.12

  A hit generation and exploration approach led to the discovery of 31 (2-(4-(6-chloro-2-(4-(dimethylamino) phenyl)-3H-imidazo[4,5-b] pyridin-7-yl) piperazin-1-yl)-N-(thiazol-2-yl) acetamide), a potent, novel inhibitor of Aurora-A, Aurora-B and Aurora-C kinases with IC50 values of 0.042, 0.198 and 0.227 mu M, respectively. Compound 31 inhibits cell proliferation and has good microsomal stability. (c) 2007 Elsevier Ltd. All rights reserved.