N-[(1R)-1'-(9H-carbazol-3-ylmethyl)spiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]acetamide | 676606-93-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-[(1R)-1'-(9H-carbazol-3-ylmethyl)spiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]acetamide
• CAS: 676606-93-2
• 化学式: C₂₈H₂₉N₃O
• 分子量: 423.558
• InChiKey: FYCCIHGGLTVNRX-HHHXNRCGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  48.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-[(1R)-1'-(9H-carbazol-3-ylmethyl)spiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]acetamide 、 三氯乙酰异氰酸酯 在 sodium hydroxide 作用下， 以 二氯甲烷 、 水 为溶剂， 以65%的产率得到3-[[(1R)-1-acetamidospiro[1,2-dihydroindene-3,4'-piperidine]-1'-yl]methyl]carbazole-9-carboxamide
  参考文献：
  名称：

  Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2

  摘要：

  A series of spiropiperidine carbazoles were synthesized and evaluated as MCHR2 antagonists using a FLIPR assay. The pharmacokinetic properties of selected compounds have also been studied. This effort led to the discovery of potent and specific MCHR2 antagonists. Compound 38 demonstrated good pharmacokinetic properties across rat, beagle dog and rhesus monkey and had a favorable selectivity profile against a number of other receptors. These MCHR2 antagonists are considered appropriate tool compounds for study of the function of MCHR2 in vivo. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.10.125
• 作为产物：
  描述：

  2,3-二氢-3-氧代螺[1H-茚-1,4’-哌啶]-1’-甲酸叔丁酯 在 盐酸 、 硼烷四氢呋喃络合物 、 叠氮磷酸二苯酯 、 水 、 三乙酰氧基硼氢化钠 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 三乙胺 、 三苯基膦 、 (S)-2-甲基-CBS-恶唑硼烷 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 二氯甲烷 、 乙酸乙酯 为溶剂， 生成 N-[(1R)-1'-(9H-carbazol-3-ylmethyl)spiro[1,2-dihydroindene-3,4'-piperidine]-1-yl]acetamide
  参考文献：
  名称：

  Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2

  摘要：

  A series of spiropiperidine carbazoles were synthesized and evaluated as MCHR2 antagonists using a FLIPR assay. The pharmacokinetic properties of selected compounds have also been studied. This effort led to the discovery of potent and specific MCHR2 antagonists. Compound 38 demonstrated good pharmacokinetic properties across rat, beagle dog and rhesus monkey and had a favorable selectivity profile against a number of other receptors. These MCHR2 antagonists are considered appropriate tool compounds for study of the function of MCHR2 in vivo. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.10.125

文献信息

• Piperidine derivatives
  申请人：Chen Xiaoqi

  公开号：US20070078152A1

  公开（公告）日：2007-04-05

  Compounds, compositions and methods are provided that are useful in the treatment or prevention of conditions or disorders associated with a neuropeptide receptor. The subject methods are particularly useful in the treatment and/or prevention of endocrine, metabolic, cardiovascular, neurologic, psychiatric, gastrointestinal, genitourinary and other disorders.
• Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2
  作者：Xiaoqi Chen、Jeff Mihalic、Pingchen Fan、Lingming Liang、Michelle Lindstrom、Sylvia Wong、Qiuping Ye、Ying Fu、Juan Jaen、Jin-Long Chen、Kang Dai、Leping Li

  DOI：10.1016/j.bmcl.2011.10.125

  日期：2012.1

  A series of spiropiperidine carbazoles were synthesized and evaluated as MCHR2 antagonists using a FLIPR assay. The pharmacokinetic properties of selected compounds have also been studied. This effort led to the discovery of potent and specific MCHR2 antagonists. Compound 38 demonstrated good pharmacokinetic properties across rat, beagle dog and rhesus monkey and had a favorable selectivity profile against a number of other receptors. These MCHR2 antagonists are considered appropriate tool compounds for study of the function of MCHR2 in vivo. (C) 2011 Elsevier Ltd. All rights reserved.