Antioquine | 93767-27-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Antioquine
• 英文别名: (1R,14S)-9,20,25-trimethoxy-15,30-dimethyl-23-oxa-15,30-diazaheptacyclo[22.6.2.13,7.18,12.114,18.027,31.022,33]pentatriaconta-3(35),4,6,8,10,12(34),18,20,22(33),24,26,31-dodecaene-6,21-diol
• CAS: 93767-27-2
• 化学式: C₃₇H₄₀N₂O₆
• 分子量: 608.7
• InChiKey: MNNXIEANPHEHSB-WDYNHAJCSA-N

物化性质

• 沸点：
  745.7±60.0 °C(Predicted)
• 密度：
  1.229±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  45
• 可旋转键数：
  3
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  83.9
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• PERMANENTLY CHARGED SODIUM AND CALCIUM CHANNEL BLOCKERS AS ANTI-INFLAMMATORY AGENTS
  申请人：President and Fellows of Harvard College

  公开号：EP3485881A1

  公开（公告）日：2019-05-22

  The present invention relates to a composition, optionally a pharmaceutical composition, comprising cysteine-derived compounds as defined in Formula (XII). The compound may be used in a method for treating neurogenic inflammation in a human patient.

  本发明涉及一种组合物，也可以是一种药物组合物，其中包含如式（XII）所定义的半胱氨酸衍生化合物。该化合物可用于治疗人类患者神经源性炎症的方法中。
• Permanently charged sodium and calcium channel blockers as anti-inflammatory agents
  申请人：Children's Medical Center Corporation

  公开号：US10729664B2

  公开（公告）日：2020-08-04

  The invention provides compounds, compositions, methods, and kits for the treatment of neurogenic inflammation.

  本发明提供了用于治疗神经源性炎症的化合物、组合物、方法和试剂盒。
• Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of central nervous system damage
  申请人：Stephenson T. Diane

  公开号：US20050159403A1

  公开（公告）日：2005-07-21

  The present invention provides compositions and methods for the treatment of central nervous system damage in a subject. More particularly, the invention provides a combination therapy for the treatment of a vaso-occlusive event, such as a stroke, comprising the administration to a subject of a calcium modulating agent and a cyclooxygenase-2 selective inhibitor.

  本发明提供了治疗受试者中枢神经系统损伤的组合物和方法。更具体地说，本发明提供了一种治疗血管闭塞事件（如中风）的组合疗法，包括向受试者施用钙调节剂和环氧合酶-2 选择性抑制剂。
• Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of pain, inflammation or inflammation mediated disorders
  申请人：Stephenson T. Diane

  公开号：US20060135506A1

  公开（公告）日：2006-06-22

  The present invention provides compositions and methods for the treatment of pain, inflammation or inflammation mediated disorders in a subject. More particularly, the invention provides a combination therapy for the treatment of pain, inflammation or inflammation mediated disorders comprising the administration to a subject of a calcium modulating agent in combination with a cyclooxygenase-2 selective inhibitor.

  本发明提供了治疗受试者疼痛、炎症或炎症介导的疾病的组合物和方法。更具体地说，本发明提供了一种治疗疼痛、炎症或炎症介导的疾病的组合疗法，包括向受试者施用钙调节剂与环氧化酶-2 选择性抑制剂。
• EP2995303A1
  申请人：——

  公开号：EP2995303A1

  公开（公告）日：2016-03-16