neocarzilin A | 124958-29-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: neocarzilin A
• 英文别名: (3Z,5E,7E,9E)-1,1,1-trichloro-4-hydroxy-11-methyltrideca-3,5,7,9-tetraen-2-one
• CAS: 124958-29-8
• 化学式: C₁₄H₁₇Cl₃O₂
• 分子量: 323.647
• InChiKey: XOJPDOWNAJBCPS-SXSRSLQCSA-N

物化性质

• 沸点：
  381.6±42.0 °C(Predicted)
• 密度：
  1.230±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 neocarzilin A 生成 neocarzilin A methyl ether
  参考文献：
  名称：

  Neocarzilins A and B, Novel Polyenones from Streptomyces Carzinostaticus

  摘要：

  Novel chlorinated polyenones, neocarzilins A (1) and B (2) have been isolated from the mycelium of Streptomyces carzinostaticus var. F41 and their structures were determined on the basis of spectroscopic analysis. Neocarzilin A (1) showed potent antileukemic activity.

  DOI：

  10.1016/s0040-4039(00)60820-1

文献信息

• Processes and host cells for genome, pathway, and biomolecular engineering
  申请人：enEvolv, Inc.

  公开号：US10370654B2

  公开（公告）日：2019-08-06

  The present disclosure provides compositions and methods for genomic engineering.

  本公开提供了基因组工程的组合物和方法。
• PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING
  申请人：ENEVOLV, INC.

  公开号：US20160186168A1

  公开（公告）日：2016-06-30

  The present disclosure provides compositions and methods for genomic engineering.
• US9944925B2
  申请人：——

  公开号：US9944925B2

  公开（公告）日：2018-04-17
• Neocarzilins A and B, Novel Polyenones from Streptomyces Carzinostaticus
  作者：Shigeo Nozoe、Naoyuki Ishii、Genjiro Kusano、Kohichi Kikuchi、Tomihisa Ohta

  DOI：10.1016/s0040-4039(00)60820-1

  日期：——

  Novel chlorinated polyenones, neocarzilins A (1) and B (2) have been isolated from the mycelium of Streptomyces carzinostaticus var. F41 and their structures were determined on the basis of spectroscopic analysis. Neocarzilin A (1) showed potent antileukemic activity.