Candicidin D | 39372-30-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Candicidin D
• 英文别名: (23E,25E,27E,29E,31E,33E,35E)-22-[(3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-38-[7-(4-aminophenyl)-5-hydroxy-4-methyl-7-oxoheptan-2-yl]-10,12,14,18,20-pentahydroxy-37-methyl-2,4,8,16-tetraoxo-1-oxacyclooctatriaconta-23,25,27,29,31,33,35-heptaene-19-carboxylic acid
• CAS: 39372-30-0
• 化学式: C₅₉H₈₄N₂O₁₈
• 分子量: 1109.3
• InChiKey: OPGSFDUODIJJGF-JBUZINEHSA-N

物化性质

• 沸点：
  1273.3±65.0 °C(Predicted)
• 密度：
  1.30±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  79
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  364
• 氢给体数：
  11
• 氢受体数：
  20

文献信息

• [EN] UREA DERIVATIVES OF POLYENE MACROLIDE ANTIBIOTICS<br/>[FR] DÉRIVÉS D'URÉE D'ANTIBIOTIQUES MACROLIDES POLYÉNIQUES
  申请人：UNIV ILLINOIS

  公开号：WO2016040779A1

  公开（公告）日：2016-03-17

  Disclosed are urea derivatives of polyene macrolide antibiotics, other than amphotericin B, comprising a urea-containing substructure represented by wherein R represents hydrogen, alkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, aminoalkyl, or -(CH2)n-COOH; and n is 1, 2, 3, 4, 5, or 6. Also disclosed are pharmaceutical compositions comprising the urea derivatives, methods of using the urea derivatives to inhibit growth of a yeast or fungus, and methods of treating a yeast or fungal infection. In various embodiments, the polyene macrolide antibiotic is selected from the group consisting of amphotericin A, arenomycin B, candicidin D, candidin, candidoin, CE-108, etruscomycin, eurocidin D, eurocidin E, FR-008-VI, HA-2-91, hamycin A, levorin AO, levorin A3, mycoheptin, natamycin (pimaricin), nystatin Al, nystatin A2, nystatin A3, partricin A, polyfungin B, rimocidin, tetramycin A, tetramycin B, tetrin A, tetrin B, tetrin C, trichomycin A, trichomycin B, vacidin A, YS-822A, 3874 HI, 3874 H2, 3874 H3, and 67-121-A.

  本发明涉及聚烯烃大环内酰胺类抗生素的脲衍生物，除了两性霉素B以外，包括一个含有脲基的亚结构，其表示为其中R表示氢、烷基、芳基、芳基烷基、杂芳基、杂芳基烷基、氨基烷基或-(CH2)n-COOH; n为1、2、3、4、5或6。本发明还涉及包含该脲衍生物的制药组合物，使用该脲衍生物抑制酵母或真菌生长的方法以及治疗酵母或真菌感染的方法。在各种实施方式中，聚烯烃大环内酰胺类抗生素选自以下组合：两性霉素A、阿诺霉素B、卡地西丁D、卡地西丁、卡地多因、CE-108、埃特鲁斯科霉素、欧洲杀菌素D、欧洲杀菌素E、FR-008-VI、HA-2-91、哈米霉素A、左旋霉素AO、左旋霉素A3、霉菌肝素、纳他霉素（皮马霉素）、制霉素Al、制霉素A2、制霉素A3、帕特里辛A、多菌灵B、利莫西汀、四菌素A、四菌素B、四菌素C、三联霉素A、三联霉素B、瓦西丁A、YS-822A、3874 HI、3874 H2、3874 H3和67-121-A。
• Processes and host cells for genome, pathway, and biomolecular engineering
  申请人：enEvolv, Inc.

  公开号：US10370654B2

  公开（公告）日：2019-08-06

  The present disclosure provides compositions and methods for genomic engineering.

  本公开提供了基因组工程的组合物和方法。
• Use of a polyene macrolide antifungal agent in combination with a glycopeptide antibacterial agent
  申请人：——

  公开号：US20040242505A1

  公开（公告）日：2004-12-02

  This invention is directed to methods of administering a polyene macrolide antifungal agent in combination with a glycopeptide antibacterial agent having a substituent comprising at least about 8 carbon atoms. The invention is also directed to methods of using a polyene macrolide antifungal agent in combination with a specified glycopeptide antibacterial agent to treat fungal infections; and to compositions, kits and systems comprising a polyene macrolide antifungal agent and a specified glycopeptide antibacterial agent.

  本发明涉及将多烯大环内酯类抗真菌剂与具有至少约 8 个碳原子取代基的糖肽类抗菌剂结合使用的方法。本发明还涉及使用多烯大环内酯抗真菌剂与特定糖肽抗菌剂联合治疗真菌感染的方法；以及包含多烯大环内酯抗真菌剂和特定糖肽抗菌剂的组合物、试剂盒和系统。
• Genes for synthesis of FR-008 polyketides
  申请人：Lee Yup Sang

  公开号：US20050089884A1

  公开（公告）日：2005-04-28

  The present invention relates to the base sequence of whole genes involved in the biosynthesis of FR-008 polyketides derived from Streptomyces sp. FR-008. This base sequence comprises genes coding for ketosynthase (KS), acyl transferase (AT), acyl carrier protein (ACP), ketoreductase (KR), dehydratase (DH) and enoyl reductase (ER) domains, and genes coding for modifier enzymes, such as ABC transporter, cytochrome P450 monooxygenase, ferredoxin, thioesterase, sugar synthetic protein, FAD-dependent monooxygenase, 4-amino-4-deoxychorismate (ADC) synthase and ADC lyase. The gene base sequence according to the present invention can be used to increase the productivity of the existing FR-008 polyketides or produce new FR-008 polyketides, through modification of its parts.

  本发明涉及参与 FR-008 多酮生物合成的全基因的碱基序列，这些多酮来自于 链霉菌 sp.FR-008。该碱基序列包括编码酮合成酶（KS）、酰基转移酶（AT）、酰基载体蛋白（ACP）、酮还原酶（KR）、脱水酶（DH）和烯酰还原酶（ER）结构域的基因，以及编码修饰酶的基因、如 ABC 转运体、细胞色素 P450 单氧化酶、铁氧还蛋白、硫酯酶、糖合成蛋白、FAD 依赖性单氧化酶、4-氨基-4-脱氧胆酸盐（ADC）合成酶和 ADC 裂解酶。根据本发明的基因碱基序列，通过对其部分进行修改，可用于提高现有 FR-008 多酮的生产率或生产新的 FR-008 多酮。
• ANTIBIOTICS
  申请人：BRITISH TECHNOLOGY GROUP LIMITED

  公开号：EP0825995A1

  公开（公告）日：1998-03-04