3-[2-[4-(4-氟苯甲酰)-1-哌啶基]乙基]-2,7-二甲基-4H-吡啶并[1,2-a]嘧啶-4-酮 | 81043-56-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3-[2-[4-(4-氟苯甲酰)-1-哌啶基]乙基]-2,7-二甲基-4H-吡啶并[1,2-a]嘧啶-4-酮
• 中文别名: 甲仑哌隆
• 英文名称: Metrenperone
• 英文别名: 3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-2,7-dimethylpyrido[1,2-a]pyrimidin-4-one
• CAS: 81043-56-3
• 化学式: C₂₄H₂₆FN₃O₂
• 分子量: 407.5
• InChiKey: AXQRPYKSPHUOGZ-UHFFFAOYSA-N

物化性质

• 熔点：
  176 °C
• 沸点：
  561.5±60.0 °C(Predicted)
• 密度：
  1.24±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO（略微加热）、甲醇（略微加热）

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  53
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• Novel derivatives of gamma-cyclodextrin
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP0197571A2

  公开（公告）日：1986-10-15

  Novel γ-cyclodextrin derivatives which are γ-cyclodextrin substituted with C1-C6 alkyl, hydroxy C1-C6 alkyl, carboxy C1-C6 alkyl or C1-C6 alkyloxycarbonylC,-C6 alkyl or mixed ethers thereof and their preparation. Compositions comprising such cyclodextrin derivatives and an active ingredient which is preferably a drug and the preparation of such compositions.

  用C1-C6烷基、羟基C1-C6烷基、羧基C1-C6烷基或C1-C6烷氧羰基C,-C6烷基或其混合醚取代的γ-环糊精新型衍生物及其制备方法。由此类环糊精衍生物和活性成分（最好是药物）组成的组合物及其制备方法。
• A new universally applicable detection system based 0n ultra small colloidal metal particles
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP0317001A1

  公开（公告）日：1989-05-24

  An aggregate for qualitatively or quantitatively determining bindable substances. Said aggregate comprises an ultra small colloidal particle and a specific binding agent characterized in that the mean diameter of the colloidal particle is below 2 nm. Preferably the size of the metal particle is selected so that the aggregate is capable of penetrating in standard biological specimens. A universally applicable detection system for determining bindable substances in particular in living material. Further there is provided a process for preparing said aggregate.

  一种用于定性或定量测定可结合物质的聚合体。所述聚合体由超小胶体颗粒和特异性结合剂组成，其特征在于胶体颗粒的平均直径低于 2 纳米。最好选择金属颗粒的尺寸，以便该聚合体能够穿透标准生物样本。一种普遍适用的检测系统，用于确定可结合物质，特别是生物材料中的可结合物质。此外，还提供了制备所述聚合体的工艺。
• Derivatives of gamma-cyclodextrin
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP0636634A1

  公开（公告）日：1995-02-01

  Novel γ-cyclodextrin derivatives which are γ-cyclodextrin substituted with C₁-C₆ alkyl, hydroxy C₁-C₆ alkyl, carboxy C₁-C₆ alkyl or C₁-C₆ alkyloxycarbonyl C₁-C₆ alkyl or mixed ethers thereof and their preparation.

  用 C₁-C₆ 烷基、羟基 C₁-C₆ 烷基、羧基 C₁-C₆ 烷基或 C₁-C₆ 烷氧羰基 C₁-C₆ 烷基或其混合醚取代的新型 γ-环糊精衍生物及其制备方法。
• COMPOUNDS FOR TREATING PAIN SYNDROME AND OTHER DISORDERS
  申请人：VM Therapeutics LLC

  公开号：EP3106166A1

  公开（公告）日：2016-12-21

  The present invention provides the use of compounds having a structural formula (I) shown below for treating peripheral or central pain syndrome and other disorders associated with the T-type calcium ion channels,

  本发明提供了具有下图所示结构式（I）的化合物用于治疗外周或中枢疼痛综合征以及与 T 型钙离子通道相关的其他疾病、