3-[2-[4-(4-氟苯甲酰基)-1-哌啶基]乙基]-2,3-二氢-2-硫代-4-(1H)-喹唑啉酮盐酸盐 | 1135280-78-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3-[2-[4-(4-氟苯甲酰基)-1-哌啶基]乙基]-2,3-二氢-2-硫代-4-(1H)-喹唑啉酮盐酸盐
• 英文名称: Altanserin hydrochloride
• 英文别名: 3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-2-sulfanylidene-1H-quinazolin-4-one;hydrochloride
• CAS: 1135280-78-2
• 化学式: C22H23ClFN3O2S
• 分子量: 448.0
• InChiKey: JFPPLMAMMZZOEA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.21
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  84.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• EP2727473A2
  申请人：——

  公开号：EP2727473A2

  公开（公告）日：2014-05-07
• COMBINATION OF EFFECTIVE SUBSTANCES CAUSING SYNERGISTIC EFFECTS OF MULTIPLE TARGETING AND USE THEREOF
  申请人：Lee Doo Hyun

  公开号：US20150290181A1

  公开（公告）日：2015-10-15

  Disclosed are a combination of active components inducing synergistic effects of multi-targeting and a use thereof. More particularly, disclosed are a functional food composition, a cosmetic composition, a pain-suppressive composition, and a composition for treatment or prevention of pruritus or atopic dermatitis, which comprise as active components, two or more components selected from a group consisting of (a) a 5-hydroxytryptamine subtype 2 (5-HT2) receptor antagonist; (b) a P2X receptor antagonist; and (c) any one of a glycine receptor agonist, a glycine transporter (GlyT) antagonist, a gamma-aminobutyric acid (GABA) receptor agonist, and a GABA transporter 1 (GAT1) antagonist. The multi-targeting composite composition (specifically, natural substances composite composition) has synergistic effects, and thus a treatment using a combination of respective components may achieve increased biological effects, in which mechanisms targeted by respective components are involved. Thus, the multi-targeting composite composition may not only remarkably control pain but may also increase effects of: alleviating symptoms of skin diseases such as itching and atopic dermatitis; preventing or improving depression, refreshment, pore minimization, improving wrinkles, skin regeneration, skin health, recovery of skin condition, skin whitening, preventing or improving athlete's foot, recovery of scalp health and regeneration of scalp, promoting hair growth, preventing gray hair, and improving dental and periodontal diseases, etc.
• US9526718B2
  申请人：——

  公开号：US9526718B2

  公开（公告）日：2016-12-27