Nystatin A2 | 65086-32-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Nystatin A2
• 英文别名: (1R,3S,7R,9R,11R,15S,16R,17R,18S,19E,21E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,7,9,11,17,37-heptahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,25,27,29,31-hexaene-36-carboxylic acid
• CAS: 65086-32-0
• 化学式: C₄₇H₇₅NO₁₆
• 分子量: 910.1
• InChiKey: RALQCAVZSAUESR-XTEMEEEFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  64
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  299
• 氢给体数：
  11
• 氢受体数：
  17

文献信息

• RESTORING PHYSIOLOGY WITH SMALL MOLECULE MIMICS OF MISSING PROTEINS
  申请人：The Board of Trustees of the University of Illinois

  公开号：US20180015115A1

  公开（公告）日：2018-01-18

  Disclosed are methods for treating a disease or condition characterized by decreased expression or reduced function of an ion channel, comprising administering to a subject in need thereof a therapeutically effective amount of a pore-forming polyene macrolide or pore-forming derivative thereof. For example, the pore-forming polyene macrolide may be amphotericin B (AmB), nystatin, or natamycin. The methods can be used to treat cystic fibrosis.