3-[4-氨基-1-(1-甲基乙基)-1H-吡唑[3,4-D]嘧啶-3-基]苯酚 | 833481-69-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 3-[4-氨基-1-(1-甲基乙基)-1H-吡唑[3,4-D]嘧啶-3-基]苯酚
• 英文名称: 1-isopropyl-3-(3-phenolyl)-4-amino-1H-pyrazolo[3,4-d]pyrimidine
• 英文别名: 3-[4-Amino-1-(1-Methylethyl)-1h-Pyrazolo[3,4-D]pyrimidin-3-Yl]phenol；3-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)phenol
• CAS: 833481-69-9
• 化学式: C₁₄H₁₅N₅O
• 分子量: 269.306
• InChiKey: MWYBBCLGEHZSCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  89.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF
  申请人：The Regents of the University of California

  公开号：US20160168151A1

  公开（公告）日：2016-06-16

  This invention generally relates to pyrazolo pyrimidine derivatives useful as, inter alia, inhibitors of short chain dehydrogenase/reductase (SDR) family of NAD(P)(H) dependent oxido-reductases. More specifically, the invention relates to pyrazolo pyrimidine derivatives, including derivatives and analogs of SDR inhibitors, pharmaceutical compositions containing derivatives and analogs of SDR inhibitors, methods of making derivatives and analogs of SDR inhibitors and methods of use thereof.

  本发明通常涉及作为短链脱氢酶/还原酶（SDR）家族NAD（P）（H）依赖性氧化还原酶的抑制剂的吡唑嘧啶衍生物。更具体地，本发明涉及吡唑嘧啶衍生物，包括SDR抑制剂的衍生物和类似物，含有SDR抑制剂的衍生物和类似物的制药组合物，制备SDR抑制剂的衍生物和类似物的方法以及其使用方法。
• Pyrazolo Pyrimidine Derivatives and Methods of Use Thereof
  申请人：Tanaka Masahiro

  公开号：US20120065154A1

  公开（公告）日：2012-03-15

  This invention generally relates to pyrazolo pyrimidine derivatives useful as, inter alia, inhibitors of short chain dehydrogenase/reductase (SDR) family of NAD(P)(H) dependent oxido-reductases. More specifically, the invention relates to pyrazolo pyrimidine derivatives, including derivatives and analogs of SDR inhibitors, pharmaceutical compositions containing derivatives and analogs of SDR inhibitors, methods of making derivatives and analogs of SDR inhibitors and methods of use thereof.

  本发明通常涉及吡唑并嘧啶衍生物，可用作短链脱氢酶/还原酶（SDR）家族的NAD（P）（H）依赖性氧化还原酶的抑制剂等。更具体地，本发明涉及吡唑并嘧啶衍生物，包括SDR抑制剂的衍生物和类似物，含有SDR抑制剂的衍生物和类似物的制药组合物，制备SDR抑制剂的衍生物和类似物的方法以及使用它们的方法。
• ANTI-INFLAMMATORY PYRAZOLOPYRIMIDINES
  申请人：Shokat Kevan M.

  公开号：US20090124638A1

  公开（公告）日：2009-05-14

  The present invention provides anti-inflammatory compounds useful in the treatment of diseases and conditions in which inflammation is involved in disease progression or the manifestation of symptoms of the disease or condition.
• Anti-Inflammatory Pyrazolopyrimndines
  申请人：Shokat Kevan M.

  公开号：US20110144134A1

  公开（公告）日：2011-06-16

  The present invention provides anti-inflammatory compounds useful in the treatment of diseases and conditions in which inflammation is involved in disease progression or the manifestation of symptoms of the disease or condition.
• QUINOLIZINONE DERIVATIVES AS PI3K INHIBITORS
  申请人：Lupin Limited

  公开号：US20170137421A1

  公开（公告）日：2017-05-18

  Disclosed are compounds of formula (I), their tautomeric forms, stereoisomers, and pharmaceutically acceptable salts thereof, wherein R 1 -R 4 , and n are as defined in the specification, pharmaceutical compositions including a compound, tautomer, stereoisomer, or salt thereof, and methods of treating or preventing diseases or disorders, for example, cancer, that are amenable to treatment or prevention by inhibiting the PI3K enzyme of a subject.