Ethyl 4-formyl-1-(2-methoxyphenyl)-1H-pyrazole-3-carboxylate | 1364523-65-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: Ethyl 4-formyl-1-(2-methoxyphenyl)-1H-pyrazole-3-carboxylate
• 英文别名: ethyl 4-formyl-1-(2-methoxyphenyl)pyrazole-3-carboxylate
• CAS: 1364523-65-8
• 化学式: C₁₄H₁₄N₂O₄
• 分子量: 274.276
• InChiKey: SIASNOOUTFUCHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  70.4
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• ORTHO SUBSTITUTED PHENYLPYRAZOLO- AND PHENYLPYRROLO-PYRIDAZINE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
  申请人：ESTEVE PHARMACEUTICALS, S.A.

  公开号：US20190284195A1

  公开（公告）日：2019-09-19

  The present invention relates to ortho substituted phenylpyrazolo- and pyrrolo-pyridazine derivatives having dual pharmacological activity towards both the α2δ subunit, in particular the α2δ-1 subunit, of the voltage-gated calcium channel and the μ-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

  本发明涉及具有双重药理活性的邻位取代苯基吡唑基和吡咯基吡啶嗪衍生物，其对电压门控钙通道的α2δ亚单位，特别是α2δ-1亚单位，和μ-阿片受体具有双重药理活性，以及这些化合物的制备过程，包含它们的药物组合物，以及它们在治疗中的使用，特别是用于疼痛治疗。
• Ortho substituted phenylpyrazolo- and phenylpyrrolo-pyridazine derivatives having multimodal activity against pain
  申请人：ESTEVE PHARMACEUTICALS, S.A.

  公开号：US10562908B2

  公开（公告）日：2020-02-18

  The present invention relates to ortho substituted phenylpyrazolo- and pyrrolo-pyridazine derivatives having dual pharmacological activity towards both the α2δ subunit, in particular the α2δ-1 subunit, of the voltage-gated calcium channel and the μ-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.

  本发明涉及对电压门控钙通道的α2δ亚基（尤其是α2δ-1亚基）和μ-阿片受体具有双重药理活性的邻位取代苯基吡唑和吡咯哒嗪衍生物，涉及这类化合物的制备工艺，涉及含有这类化合物的药物组合物，还涉及它们在治疗中的用途，尤其是用于治疗疼痛。