1-(6-Methoxypyridin-2-YL)cyclopropane-1-carboxylic acid | 1060807-01-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(6-Methoxypyridin-2-YL)cyclopropane-1-carboxylic acid
• 英文别名: 1-(6-methoxypyridin-2-yl)cyclopropane-1-carboxylic acid
• CAS: 1060807-01-3
• 化学式: C₁₀H₁₁NO₃
• 分子量: 193.2
• InChiKey: QWOZINGRPSBARY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  59.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(6-Methoxypyridin-2-YL)cyclopropanecarbonitrile 在 水 、 sodium hydroxide 作用下， 以 乙醇 为溶剂， 生成 1-(6-Methoxypyridin-2-YL)cyclopropane-1-carboxylic acid
  参考文献：
  名称：

  ALPHA-V-BETA-8 INTEGRIN INHIBITORS AND USES THEREOF

  摘要：

  The disclosure relates to compounds of formula (A) and formula (I), e.g.: (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, L1, L2, L3, Y, and Q are as described herein. Compounds of formula (A) and formula (I) and pharmaceutical compositions thereof are inhibitors of at least one or more of avPs, avPi, and avPe integrins. Also disclosed are methods for treating fibrosis such as nonalcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP), and cancer comprising administration of the compounds and pharmaceutical compositions thereof.

  公开号：

  WO2024145245A2

文献信息

• ALPHA-V-BETA-8 INTEGRIN INHIBITORS AND USES THEREOF
  申请人：[en]PLIANT THERAPEUTICS, INC.

  公开号：WO2024145245A2

  公开（公告）日：2024-07-04

  The disclosure relates to compounds of formula (A) and formula (I), e.g.: (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, L1, L2, L3, Y, and Q are as described herein. Compounds of formula (A) and formula (I) and pharmaceutical compositions thereof are inhibitors of at least one or more of avPs, avPi, and avPe integrins. Also disclosed are methods for treating fibrosis such as nonalcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP), and cancer comprising administration of the compounds and pharmaceutical compositions thereof.