6-Chloro-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one | 337463-99-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-Chloro-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
• 英文别名: 6-chloro-4H-pyrido[3,2-b][1,4]oxazin-3-one
• CAS: 337463-99-7
• 化学式: C₇H₅ClN₂O₂
• 分子量: 184.58
• InChiKey: VNQSVVITTNQXLY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Aminopiperidine derivatives
  申请人：GLAXO GROUP LIMITED

  公开号：EP2181996A1

  公开（公告）日：2010-05-05

  Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.

  哌啶衍生物及其药学上可接受的衍生物，可用于治疗哺乳动物，尤其是人类的细菌感染。
• Heterocyclic compounds useful as anti-bacterial agents and method for production thereof
  申请人：Bugworks Research, Inc.

  公开号：US10912780B2

  公开（公告）日：2021-02-09

  The present disclosure relates to compounds of Formula I, or their stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivatives thereof, and pharmaceutical compositions containing them as the active ingredient which can be used as medicaments. The aforementioned substances can also be used in the manufacture of medicaments for treatment, prevention or suppression of diseases, and conditions mediated by microbes. The present disclosure also relates to the synthesis and characterization of aforementioned substances.

  本公开涉及式 I 化合物或其立体异构体、药学上可接受的盐、络合物、水合物、溶 液物、同系物、多晶型物、外消旋混合物、光学活性形式及其药学活性衍生物，以及含 有它们作为活性成分的可用作药物的药物组合物。上述物质还可用于制造治疗、预防或抑制由微生物介导的疾病和病症的药物。本公开还涉及上述物质的合成和表征。
• HETEROCYCLIC COMPOUNDS USEFUL AS ANTI-BACTERIAL AGENTS AND METHOD FOR PRODUCTION THEREOF
  申请人：Bugworks Research, Inc.

  公开号：US20200085834A1

  公开（公告）日：2020-03-19

  The present disclosure relates to compounds of Formula I, or their stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivatives thereof, and pharmaceutical compositions containing them as the active ingredient which can be used as medicaments. The aforementioned substances can also be used in the manufacture of medicaments for treatment, prevention or suppression of diseases, and conditions mediated by microbes. The present disclosure also relates to the synthesis and characterization of aforementioned substances.
• ANTI-BACTERIAL HETEROCYCLIC COMPOUNDS AND THEIR SYNTHESIS
  申请人：Bugworks Research Inc.

  公开号：US20210070772A1

  公开（公告）日：2021-03-11

  The invention relates to compounds of Formula I and Formula (B) along with their stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms, and pharmaceutically active derivatives thereof. These compounds are useful for killing or inhibiting the growth of a microorganism selected from the group consisting of bacteria, virus, fungi, and protozoa.