2,3,4-trifluoro-N-[[(5R)-3-(3-fluoro-4-morpholino-phenyl)-2-oxo-oxazolidin-5-yl]methyl]benzenesulfonamide | 1430414-17-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 2,3,4-trifluoro-N-[[(5R)-3-(3-fluoro-4-morpholino-phenyl)-2-oxo-oxazolidin-5-yl]methyl]benzenesulfonamide
• 英文别名: 2,3,4-trifluoro-N-[[(5R)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]benzenesulfonamide
• CAS: 1430414-17-7
• 化学式: C₂₀H₁₉F₄N₃O₅S
• 分子量: 489.448
• InChiKey: DTJQMMFBOSXXAF-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  96.6
• 氢给体数：
  1
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  吗啉恶酮相关物质A 在 palladium on activated charcoal 、 氢气 、 三乙胺 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 为溶剂， 反应 7.0h， 生成 2,3,4-trifluoro-N-[[(5R)-3-(3-fluoro-4-morpholino-phenyl)-2-oxo-oxazolidin-5-yl]methyl]benzenesulfonamide
  参考文献：
  名称：

  Synthesis, biological evaluation of new oxazolidino-sulfonamides as potential antimicrobial agents

  摘要：

  A number of linezolid-like oxazolidino-sulfonamides (7a-y and 8a-b) were designed and synthesized with a view to develop antimicrobial agents with improved properties. Most of the synthesized compounds showed good to moderate activity against a panel of standard Gram-positive and Gram-negative bacteria and fungal strains. The compounds 7i and 7v exhibited significant activity, with a MIC value of 2.0-6.0 mu g/mL against a panel of Gram-positive and Gram-negative bacteria. These compounds also showed activity against Candida albicans, with a MIC value of 4.0 mu g/mL. A correlation of the antimicrobial activity with calculated lipophilicity values (C log P) is also presented. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.01.034