[9-(2-hexyl-1,3-dioxolan-2-yl)nonyl]triphenylphosphonium bromide | 1421940-20-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [9-(2-hexyl-1,3-dioxolan-2-yl)nonyl]triphenylphosphonium bromide
• 英文别名: 9-(2-Hexyl-1,3-dioxolan-2-yl)nonyl-triphenylphosphanium;bromide；9-(2-hexyl-1,3-dioxolan-2-yl)nonyl-triphenylphosphanium;bromide
• CAS: 1421940-20-6
• 化学式: Br*C₃₆H₅₀O₂P
• 分子量: 625.67
• InChiKey: NOKUUFCXPRNCOO-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  5.82
• 重原子数：
  40
• 可旋转键数：
  18
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [9-(2-hexyl-1,3-dioxolan-2-yl)nonyl]triphenylphosphonium bromide 在 20% palladium hydroxide-activated charcoal 、 溶剂黄146 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 乙醇 、 水 为溶剂， 反应 24.0h， 生成 (4S)-4-[(1R)-1-hydroxy-12-oxooctadecyl]-4-(hydroxymethyl)oxazolidin-2-one
  参考文献：
  名称：

  A stereoselective total synthesis of the HCl salts of mycestericins F, G and ent-F

  摘要：

  The total synthesis of the HCl salts of two natural sphingolipid-related amino acid derivatives, mycestericins F 4 and G 5 together with unnatural ent-4 center dot HCl, starting from the four crucial scaffolds 6, 8, 9, 11 and utilizing the Wittig reaction to build the C-20 backbone, has been achieved. The selection of selective functional group interconversions accompanied with suitable protection-deprotection protocols in the coupling products 20 and 34 gave the desired structures. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2012.12.003
• 作为产物：
  描述：

  9-(2-hexyl-1,3-dioxolan-2-yl)nonan-1-ol 在 N-溴代丁二酰亚胺(NBS) 、 sodium carbonate 、 三苯基膦 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 72.5h， 生成 [9-(2-hexyl-1,3-dioxolan-2-yl)nonyl]triphenylphosphonium bromide
  参考文献：
  名称：

  A stereoselective total synthesis of the HCl salts of mycestericins F, G and ent-F

  摘要：

  The total synthesis of the HCl salts of two natural sphingolipid-related amino acid derivatives, mycestericins F 4 and G 5 together with unnatural ent-4 center dot HCl, starting from the four crucial scaffolds 6, 8, 9, 11 and utilizing the Wittig reaction to build the C-20 backbone, has been achieved. The selection of selective functional group interconversions accompanied with suitable protection-deprotection protocols in the coupling products 20 and 34 gave the desired structures. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2012.12.003

文献信息

• A stereoselective total synthesis of the HCl salts of mycestericins F, G and ent-F
  作者：Miroslava Martinková、Jozef Gonda、Alena Uhríková、Jana Špaková Raschmanová、Mária Vilková、Beáta Oroszová

  DOI：10.1016/j.tetasy.2012.12.003

  日期：2013.2

  The total synthesis of the HCl salts of two natural sphingolipid-related amino acid derivatives, mycestericins F 4 and G 5 together with unnatural ent-4 center dot HCl, starting from the four crucial scaffolds 6, 8, 9, 11 and utilizing the Wittig reaction to build the C-20 backbone, has been achieved. The selection of selective functional group interconversions accompanied with suitable protection-deprotection protocols in the coupling products 20 and 34 gave the desired structures. (C) 2012 Elsevier Ltd. All rights reserved.