(E)-2-(4-chlorophenyl)-3-styryl-1H-indole | 1397586-11-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (E)-2-(4-chlorophenyl)-3-styryl-1H-indole
• 英文别名: 2-(4-chlorophenyl)-3-[(E)-2-phenylethenyl]-1H-indole
• CAS: 1397586-11-6
• 化学式: C₂₂H₁₆ClN
• 分子量: 329.829
• InChiKey: UHMDQYWIIKLFIL-XNTDXEJSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  15.8
• 氢给体数：
  1
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  2-(4-氯苯基)吲哚 、 苯乙醛 在 乙醇 、 iron(III) chloride hexahydrate 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以81%的产率得到(E)-2-(4-chlorophenyl)-3-styryl-1H-indole
  参考文献：
  名称：

  FeCl₃·6H₂O-Catalyzed Alkenylation of Indoles with Aldehydes

  摘要：

  FeCl3 center dot 6H(2)O-catalyzed efficient C3-alkenylation of indoles was realized through the condensation of aldehydes and indole derivatives in the presence of 2 equiv of ethanol at ambient temperature, forming 3-vinylindoles in up to 93% yields. Ethanol promoted formation of the desired products. An obvious solvent effect was observed, and bisindoles were identified as the reaction intermediates.

  DOI：

  10.1021/jo301416s

文献信息

• FeCl₃·6H₂O-Catalyzed Alkenylation of Indoles with Aldehydes
  作者：Qin Yang、Liandi Wang、Tenglong Guo、Zhengkun Yu

  DOI：10.1021/jo301416s

  日期：2012.9.21

  FeCl3 center dot 6H(2)O-catalyzed efficient C3-alkenylation of indoles was realized through the condensation of aldehydes and indole derivatives in the presence of 2 equiv of ethanol at ambient temperature, forming 3-vinylindoles in up to 93% yields. Ethanol promoted formation of the desired products. An obvious solvent effect was observed, and bisindoles were identified as the reaction intermediates.