1-(3,4-difluorophenyl)-2-iodo-5-(4-methylsulfonylphenyl)imidazole | 1401998-11-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(3,4-difluorophenyl)-2-iodo-5-(4-methylsulfonylphenyl)imidazole
• 英文别名: 1-(3,4-Difluorophenyl)-2-iodo-5-(4-methylsulfonylphenyl)imidazole
• CAS: 1401998-11-5
• 化学式: C₁₆H₁₁F₂IN₂O₂S
• 分子量: 460.243
• InChiKey: WGGUZSALZUSLIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  60.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 1-(3,4-difluorophenyl)-2-iodo-5-(4-methylsulfonylphenyl)imidazole
  参考文献：
  名称：

  Synthesis of 1,5-diarylhaloimidazole analogs and their inhibitory activities against PGE2 production from LPS-treated RAW 264.7 cells

  摘要：

  A number of 1,5-diarylimidazole analogs were synthesized and evaluated their inhibitory activities of cyclooxygenase-2 catalyzed prostaglandin E-2 production. Reactions of 1,5-diarylimidazoles with halogenating reagents (NCS, NBS, NIS) afforded halogenated analogs. Among the analogs tested, compounds Ib, Ha, IIb and IIe exhibited significantly improved inhibitory activities against COX-2-mediated PGE(2) production from LPS-induced RAW 264.7 cells compared to those of the parent 1,5-diarylimidazoles. Especially, the analogs Ib (IC50 = 0.55 mu M) and Ha (IC50 = 0.58 mu M) showed best results. Halogenation on the 1,5-diarylimidazole ring enhanced inhibitory activities against COX-2 catalyzed PGE(2) production, however, inhibitory activities were significantly varied by position(s) and species of the substituted halogen(s). (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.09.014

文献信息

• Synthesis of 1,5-diarylhaloimidazole analogs and their inhibitory activities against PGE2 production from LPS-treated RAW 264.7 cells
  作者：Zunhua Yang、Tuyen N. Truong、Tuan-Anh N. Pham、Jae-Won Lee、Sung-Soo Kim、Haeil Park

  DOI：10.1016/j.bmc.2012.09.014

  日期：2012.11

  A number of 1,5-diarylimidazole analogs were synthesized and evaluated their inhibitory activities of cyclooxygenase-2 catalyzed prostaglandin E-2 production. Reactions of 1,5-diarylimidazoles with halogenating reagents (NCS, NBS, NIS) afforded halogenated analogs. Among the analogs tested, compounds Ib, Ha, IIb and IIe exhibited significantly improved inhibitory activities against COX-2-mediated PGE(2) production from LPS-induced RAW 264.7 cells compared to those of the parent 1,5-diarylimidazoles. Especially, the analogs Ib (IC50 = 0.55 mu M) and Ha (IC50 = 0.58 mu M) showed best results. Halogenation on the 1,5-diarylimidazole ring enhanced inhibitory activities against COX-2 catalyzed PGE(2) production, however, inhibitory activities were significantly varied by position(s) and species of the substituted halogen(s). (C) 2012 Elsevier Ltd. All rights reserved.