3-乙氧基戊烷 | 36749-13-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3-乙氧基戊烷
• 英文名称: 1-ethylpropyl ethyl ether
• 英文别名: 3-Ethoxypentane
• CAS: 36749-13-0
• 化学式: C₇H₁₆O
• 分子量: 116.203
• InChiKey: BMAINLNHNVARHJ-UHFFFAOYSA-N

物化性质

• 熔点：
  -95.35°C (estimate)
• 沸点：
  117.3°C (estimate)
• 密度：
  0.7684 (estimate)
• 保留指数：
  773

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2909199090

反应信息

• 作为产物：
  描述：

  3,3-二乙氧基戊烷 在 三氯硅烷 作用下， 生成 3-乙氧基戊烷
  参考文献：
  名称：

  Reduction with trichlorosilane. IV. Ether from acetal

  摘要：

  DOI：

  10.1021/jo00799a025

文献信息

• [EN] INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION<br/>[FR] INHIBITEURS DE LA RÉPLICATION DU VIRUS DE L'IMMUNODÉFICIENCE HUMAINE
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2009062288A1

  公开（公告）日：2009-05-22

  The present invention relates to compounds of formula (I) wherein c, X, Y, R2, R3, R4 and R6 are as defined herein, compositions and uses thereof for treating human immunodeficiency virus (HIV) infection. In particular, the present invention provides novel inhibitors of HIV integrase, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HIV infection

  本发明涉及式（I）的化合物，其中c、X、Y、R2、R3、R4和R6如本文所定义，以及用于治疗人类免疫缺陷病毒（HIV）感染的组合物和用途。具体地，本发明提供了HIV整合酶的新型抑制剂，含有这些化合物的药物组合物以及在治疗HIV感染中使用这些化合物的方法
• Method for the production of beta-ketonitriles
  申请人：Vogelbacher Uwe Josef

  公开号：US20100105903A1

  公开（公告）日：2010-04-29

  The present invention relates to a process for preparing β-ketonitriles of the general formula I in which R 1 is, inter alia, C 1 -C 12 -alkyl, C 2 -C 12 -alkenyl, C 2 -C 12 -alkinyl, C 3 -C 8 -cycloalkyl, C 3 -C 8 -cycloalkyl-C 1 -C 4 -alkyl, phenyl-C 1 -C 4 -alkyl, phenoxy-C 1 -C 4 -alkyl or benzyloxy-C 1 -C 4 -alkyl; R 2 is, inter alia, hydrogen, C 1 -C 12 -alkyl, C 2 -C 12 -alkenyl, C 2 -C 12 -alkinyl, C 3 -C 8 -cycloalkyl, C 3 -C 8 -cycloalkyl-C 1 -C 4 -alkyl, phenyl, phenyl-C 1 -C 4 -alkyl, phenoxy-C 1 -C 4 -alkyl or benzyloxy-C 1 -C 4 -alkyl, which comprises reacting a nitrile of the formula II in which R 1 has one of the meanings given above with a carboxylic ester of the formula III in which R 2 has one of the meanings given above and R 3 is C 1 -C 12 -alkyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 3 -C 8 -cycloalkyl, C 3 -C 8 -cycloalkyl-C 1 -C 4 -alkyl, phenyl-C 1 -C 4 -alkyl, phenoxy-C 1 -C 4 -alkyl or benzyloxy-C 1 -C 4 -alkyl, where the reaction is carried out in the presence of a potassium alkoxide and at least 80% of the nitrile of the formula II are added to the reaction under reaction conditions.

  本发明涉及一种制备一般式I的β-酮腈的方法，其中R1是C1-C12-烷基、C2-C12-烯基、C2-C12-炔基、C3-C8-环烷基、C3-C8-环烷基-C1-C4-烷基、苯基-C1-C4-烷基、苯氧基-C1-C4-烷基或苄氧基-C1-C4-烷基；R2是氢、C1-C12-烷基、C2-C12-烯基、C2-C12-炔基、C3-C8-环烷基、C3-C8-环烷基-C1-C4-烷基、苯基、苯基-C1-C4-烷基、苯氧基-C1-C4-烷基或苄氧基-C1-C4-烷基。该方法包括将具有上述给定含义之一的一般式II的腈与具有上述给定含义之一的一般式III的羧酸酯反应，其中R3是C1-C12-烷基、C1-C4-烷氧基-C1-C4-烷基、C3-C8-环烷基、C3-C8-环烷基-C1-C4-烷基、苯基-C1-C4-烷基、苯氧基-C1-C4-烷基或苄氧基-C1-C4-烷基，在存在钾醇和至少80%的一般式II的腈被加入到反应中，并在反应条件下进行。
• METHOD FOR MANUFACTURING FLUORINATED HYDROCARBON
  申请人：ZEON CORPORATION

  公开号：US20180215688A1

  公开（公告）日：2018-08-02

  The present invention is a method for producing a fluorinated hydrocarbon represented by a structural formula (3), wherein an ether compound represented by a structural formula (1) and an acid fluoride represented by a structural formula (2) are brought into contact with each other in a hydrocarbon-based solvent, in the presence of a catalyst in which boron trifluoride is supported on a metal oxide: wherein R 1 and R 2 represent an alkyl group having 1 to 3 carbon atoms, R 3 represents a hydrogen atom, a methyl group or an ethyl group, and R 4 and R 5 represent a methyl group or an ethyl group; and R 4 and R 2 may be bonded to each other to form a cyclic structure. Through the present invention, a method for industrially advantageously producing 2-fluorobutane is provided.

  本发明是一种生产由结构式（3）表示的氟化碳氢化合物的方法，其中在碳氢基溶剂中，在支持三氟化硼的金属氧化物上的催化剂的存在下，将由结构式（1）表示的醚化合物和由结构式（2）表示的酸氟化物相互接触；其中R1和R2代表具有1到3个碳原子的烷基基团，R3代表氢原子、甲基基团或乙基基团，R4和R5代表甲基基团或乙基基团；R4和R2可以相互连接形成环状结构。通过本发明，提供了一种有利于工业生产2-氟丁烷的方法。
• METHOD FOR PRODUCING FLUORINATED HYDROCARBON
  申请人：ZEON CORPORATION

  公开号：US20170174588A1

  公开（公告）日：2017-06-22

  The present invention is a method for producing a fluorohydrocarbon represented by a structural formula (3) comprising bringing a secondary or tertiary ether compound represented by a structural formula (1) into contact with an acid fluoride represented by a structural formula (2) in a hydrocarbon-based solvent in the presence of a boron trifluoride complex. (In structural formulae (1) to (3), each of R 1 and R 2 represents an alkyl group having 1 to 3 carbon atoms, R 3 represents a hydrogen atom, a methyl group, or an ethyl group, and each of R 4 and R 5 represents a methyl group or an ethyl group, provided that R 1 and R 2 are optionally bonded to each other to form a ring structure.)

  本发明是一种生产由结构式（3）表示的氟碳氢化合物的方法，包括在碳氢基溶剂中，将由结构式（1）表示的二次或三次醚化合物与由结构式（2）表示的酸氟化物在三氟化硼络合物存在下接触。在结构式（1）到（3）中，R1和R2分别表示具有1至3个碳原子的烷基基团，R3表示氢原子、甲基基团或乙基基团，R4和R5分别表示甲基基团或乙基基团，前提是R1和R2可以选择性地结合在一起形成环结构。
• GLYCEROL DERIVATIVES AND METHODS OF MAKING SAME
  申请人：Kodali Dharma R.

  公开号：US20080293602A1

  公开（公告）日：2008-11-27

  Symmetrical polyols, polyol esters, polyesters, polyurethanes, triazoles, and polyvinylethers derived from glycerol and methods of making the symmetrical polyols, polyesters, polyurethanes, polyhydroxyvinylethers and triazoles are discussed. Also provided is a method of making serinol.

  本文讨论了从甘油衍生出的对称聚醇、聚醚醇、聚酯、聚氨酯、三唑和聚乙烯醚，以及制备这些对称聚醇、聚酯、聚氨酯、聚羟基乙烯醚和三唑的方法。此外，还提供了一种制备丝氨醇的方法。