3-吗啉-4-基-1,3-二苯基丙烷-1-酮 | 5509-82-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 中文名称: 3-吗啉-4-基-1,3-二苯基丙烷-1-酮
• 英文名称: 3-morpholin-4-yl-1,3-diphenyl-propan-1-one
• 英文别名: 3-morpholino-1,3-diphenyl-propan-1-one；3-Morpholino-1,3-diphenyl-propan-1-on；ω-<α-Morpholino-benzyl>acetophenon；(+/-)-3-Morpholino-1,3-diphenyl-propan-1-on；1-Morpholino-1,3-diphenyl-propanon-(3)；3-(Morpholin-4-yl)-1,3-diphenylpropan-1-one；3-morpholin-4-yl-1,3-diphenylpropan-1-one
• CAS: 5509-82-0
• 化学式: C₁₉H₂₁NO₂
• 分子量: 295.381
• InChiKey: PSONCHPWSNITBC-UHFFFAOYSA-N

物化性质

• 熔点：
  72-74 °C
• 沸点：
  454.0±45.0 °C(Predicted)
• 密度：
  1.135±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-吗啉-4-基-1,3-二苯基丙烷-1-酮 在 氧气 作用下， 以 甲醇 为溶剂， 以52%的产率得到(E)-3-吗啉-4-基-1,3-二苯基丙烯酮
  参考文献：
  名称：

  The influence of substituents on the photochemical generation and stability of 2-morpholinocyclopropanols

  摘要：

  By irradiation in oxygen-free ether alpha- or beta-substituted beta-morpholinopropiophenones 1a-c form the corresponding cyclopropanols 2 with 1-aryl and 2-morpholino group in a relative cis-configuration in high yields. The photocyclization of pure 1a-c enantiomers proceeds enantioselectively under these conditions. In methanol and presence of oxygen electronically excited 1c-h are converted to enaminones 3c-h via oxidation of intermediate cyclopropanols 2c-h. In the presence of electron-acceptor molecules this reaction apparently follows a SET mechanism.

  DOI：

  10.1016/s0040-4039(00)61688-x
• 作为产物：
  描述：

  trimethyl-[(Z)-3-morpholin-4-yl-1,3-diphenylprop-1-enoxy]silane 生成 3-吗啉-4-基-1,3-二苯基丙烷-1-酮
  参考文献：
  名称：

  COMBRET, J. -C.;KLEIN, J. -L.;MOUSLOUHAUDDINA, MOHAMED, TETRAHEDRON LETT., 1984, 25, N 32, 3449-3452

  摘要：

  DOI：

文献信息

• Ketones
  申请人：Barton John Peter

  公开号：US20050272036A1

  公开（公告）日：2005-12-08

  Compounds of formula (I): wherein variable groups are as defined within; for use in the inhibition of 11βHSD1 are described.

  描述了式(I)的化合物：其中变量基团如定义的那样；用于抑制11βHSD1。
• Novel substituted indolines with an inhibitory effect on various kinases and complexes of CDKs
  申请人：Boehringer Ingelheim Pharma KG

  公开号：US20040058978A1

  公开（公告）日：2004-03-25

  The present invention relates to new substituted indolinones of general formula 1 wherein X and R 1 to R 5 are defined as in claim 1, the isomers and the salts thereof which have valuable properties. The above compounds of general formula I wherein R 1 denotes a hydrogen atom, a C 1-3 -alkyl group or a prodrug group have valuable pharmacological properties, particularly an inhibiting effect on various kinases, on viral cyclin and on receptor tyrosine kinases, and the other compounds of the above general formula I wherein R 1 does not represent a hydrogen atom, a C 1-3 -alkyl group or a prodrug group are valuable intermediate products for the preparation of the abovementioned compounds.

  本发明涉及一种新的通式1的取代吲哚酮，其中X和R1至R5的定义如权利要求书1中所述，其异构体和盐具有有价值的性质。通式I中的上述化合物，其中R1表示氢原子，C1-3-烷基或前药基，具有有价值的药理学性质，特别是对多种激酶、病毒细胞周期蛋白和受体酪氨酸激酶具有抑制作用，上述通式I中R1不表示氢原子、C1-3-烷基或前药基的其他化合物是制备上述化合物的有价值中间体。
• Ueno, Satoshi; Shimizu, Ryosuke; Kuwano, Ryoichi, Angewandte Chemie - International Edition, 2009, vol. 48, p. 4543 - 4545
  作者：Ueno, Satoshi、Shimizu, Ryosuke、Kuwano, Ryoichi

  DOI：——

  日期：——
• Derivatives of Morpholine. I. Addition to Conjugate Systems. I.
  作者：Vincent E. Stewart、C. B. Pollard

  DOI：10.1021/ja01291a066

  日期：1937.12
• Matloubi Moghaddam, Firouz; Mohammadi, Mohsen; Hosseinnia, Azarmidocht, Synthetic Communications, 2000, vol. 30, # 4, p. 643 - 650
  作者：Matloubi Moghaddam, Firouz、Mohammadi, Mohsen、Hosseinnia, Azarmidocht

  DOI：——

  日期：——