3-异丙烯基异恶唑 | 35210-70-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 3-异丙烯基异恶唑
• 英文名称: 3-isopropenyl-isoxazole
• 英文别名: 3-Isopropenyl-isoxazol；3-Prop-1-en-2-yl-1,2-oxazole；3-prop-1-en-2-yl-1,2-oxazole
• CAS: 35210-70-9
• 化学式: C₆H₇NO
• 分子量: 109.128
• InChiKey: CXTPSVQSBBOEMG-UHFFFAOYSA-N

物化性质

• 沸点：
  171.8±9.0 °C(Predicted)
• 密度：
  0.980±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  26
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-异丙烯基异恶唑 生成 3-异恶唑甲酸
  参考文献：
  名称：

  Quilico; Speroni, Gazzetta Chimica Italiana, 1939, vol. 69, p. 508,512, 522

  摘要：

  DOI：
• 作为产物：
  描述：

  2-isoxazol-3-yl-propan-2-ol 在 phosphorus pentoxide 作用下， 生成 3-异丙烯基异恶唑
  参考文献：
  名称：

  Quilico; Speroni, Gazzetta Chimica Italiana, 1940, vol. 70, p. 779,786, 787

  摘要：

  DOI：

文献信息

• Separation material comprising phosphoryl choline derivatives
  申请人：Pentracor GmbH

  公开号：EP2957563A1

  公开（公告）日：2015-12-23

  The present invention provides phosphoryl choline derivatives of general formula (I), which are suitable to be immobilized on a solid support to provide a separation material, which bind with both high affinity and high specificity to a protein, more specifically to C-reactive protein and anti-phosphoryl choline antibodies. Said separation materials are particularly useful in the extracorporeal removal of C-reactive protein and anti-phosphoryl choline antibodies from a biological fluid of a patient for prophylaxis and/or treatment of immune dysfunctions and cardiovascular diseases. Also claimed is a device containing a column that comprises separation material made from formula (I) wherein L is a linker as defined in the claims; X is selected from: -SH, -NHR3, -C=CH, -CH=CH2, -N3, -CHO. Also claimed is a separation material of general formula (II): wherein A is a solid support; Y is a group obtainable from the reactive group X.

  本发明提供了一般式（I）的磷酸胆碱衍生物，适合固定在固体支架上，以提供分离材料，其具有与蛋白质高亲和力和高特异性结合的能力，更具体地结合到C-反应蛋白和抗磷酸胆碱抗体。该分离材料在从患者的生物液中外体清除C-反应蛋白和抗磷酸胆碱抗体，以预防和/或治疗免疫功能障碍和心血管疾病方面特别有用。还声明了一种包含由公式（I）制成的分离材料的柱子的装置，其中L是如权利要求中定义的连接剂;X选自：-SH，-NHR3，-C = CH，-CH = CH2，-N3，-CHO。还声明了一种一般式（II）的分离材料：其中A是固体支架; Y是从反应基团X获得的基团。
• COPOLYMER AND MOLDED BODY
  申请人：Kuraray Co., Ltd.

  公开号：EP2957579A1

  公开（公告）日：2015-12-23

  A copolymer comprising a structural unit (I) derived from a phosphonate monomer (1) such as diethyl methacryloyloxymethyl phosphonate, diethyl 2-methacryloyloxyethyl phosphonate and the like, and a structural unit (II) derived from a radical polymerizable monomer (2) such as methacrylic acid, acrylic acid, 8-tricyclo[5.2.1.02,6]decanyl methacrylate, t-butyl methacrylate and the like, wherein the content of phosphorus atoms from the phosphonate monomer (1) is 2.0 to 6.0 % by mass relative to the mass of the copolymer. A formed article comprising the copolymer.

  一种共聚物，其结构单元（I）来自膦酸盐单体（1），如甲基丙烯酰氧甲基膦酸二乙酯、2-甲基丙烯酰氧乙基膦酸二乙酯等，结构单元（II）来自可自由基聚合的单体（2），如甲基丙烯酸、丙烯酸、8-三环[5.2.1.02,6]癸基甲基丙烯酸酯、甲基丙烯酸叔丁酯等，其中膦酸酯单体（1）的磷原子含量相对于共聚物的质量为 2.0% 至 6.0%。由该共聚物组成的成型制品。
• COPOLYMER, AND MOLDED ARTICLE
  申请人：Kuraray Co., Ltd.

  公开号：EP3095800A1

  公开（公告）日：2016-11-23

  Provided are a break-resistant copolymer having high transparency and heat resistance and also having a high tensile strain at break, and a molded article. A copolymer contains 80% by mass to 98% by mass of structural units derived from a methacrylic ester monomer and 2% to 10% by mass of ester structural units derived from a cyclic ketene acetal monomer. The copolymer has a weight average molecular weight of 80, 000 or more and a molecular weight distribution of 1. 75 to 3.80.

  本发明提供了一种具有高透明度和耐热性，同时具有高断裂拉伸应变的抗断裂共聚物，以及一种模塑制品。 一种共聚物含有 80%-98%（质量百分比）由甲基丙烯酸酯单体衍生的结构单元和 2%-10%（质量百分比）由环烯酮缩醛单体衍生的酯结构单元。共聚物的平均分子量为 80,000 或以上，分子量分布为 1.75 至 3.80。
• COPOLYMER AND MOLDED ARTICLE
  申请人：Kuraray Co., Ltd.

  公开号：EP3181602A1

  公开（公告）日：2017-06-21

  A copolymer comprising a structural unit (I) derived from a phosphonate monomer (1) such as diethyl methacryloyloxymethyl phosphonate and diethyl 2-methacryloyloxyethyl phosphonate, a structural unit (II) derived from a radical polymerizable monomer (2) such as methacrylic acid, acrylic acid, 8-tricyclo[5.2.1.02,6]decanyl methacrylate, and t-butyl methacrylate, and a structural unit (III) derived from methyl methacrylate, the content of phosphorus atoms derived from the phosphonate monomer (1) being not less than 1.0% by mass and less than 2.0% by mass relative to the mass of the copolymer, and a formed article comprising the copolymer.

  一种共聚物，其结构单元(I)来自膦酸酯单体(1)，如甲基丙烯酰氧甲基膦酸二乙酯和 2-甲基丙烯酰氧乙基膦酸二乙酯；结构单元(II)来自可自由基聚合的单体(2)，如甲基丙烯酸、丙烯酸、8-三环[5.2.1.02,6]癸基甲基丙烯酸酯和甲基丙烯酸 t-丁酯，以及由甲基丙烯酸甲酯衍生的结构单元（III），相对于共聚物的质量，由膦酸酯单体（1）衍生的磷原子的含量不小于 1.0%（以质量计）且小于 2.0%（以质量计），以及由该共聚物组成的成型制品。
• METHACRYLIC COPOLYMER AND MOLDED ARTICLE
  申请人：Kuraray Co., Ltd.

  公开号：EP3564275A1

  公开（公告）日：2019-11-06

  A methacrylic copolymer having high thermal resistance and low water absorption and being hardly decomposed thermally is provided. The methacrylic copolymer comprises 5 to 22 % by mass of a structural unit derived from a monomer represented by formula (1) (in formula (1), R1 represents a hydrogen atom or a methyl group, R2 represents a 1C-4C alkyl group, and "n" is an integer of 1 to 3.) and 78 to 95 % by mass of a structural unit derived from a methacrylic acid ester monomer other than the monomer represented by the formula (1), and has a saturated water absorption of not more than 1.6 % by mass.

  本发明提供了一种具有高耐热性和低吸水性且几乎不会热分解的甲基丙烯酸共聚物。该甲基丙烯酸共聚物包括 5%至 22%（质量百分比）的结构单元，该结构单元源自式（1）所代表的单体（式（1）中，R1 代表氢原子或甲基，R2 代表 1C-4C 烷基，"n "为 1 至 3 的整数），以及 78%至 95%（质量百分比）的结构单元，该结构单元源自除式（1）所代表的单体之外的甲基丙烯酸酯单体，其饱和吸水率不超过 1.6%（质量百分比）。