3-氟-2-喹啉羧酸 | 834884-07-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 3-氟-2-喹啉羧酸
• 英文名称: 3-fluoroquinoline-2-carboxylic acid
• CAS: 834884-07-0
• 化学式: C₁₀H₆FNO₂
• 分子量: 191.162
• InChiKey: GPOCCEKHGSAOAJ-UHFFFAOYSA-N

物化性质

• 熔点：
  129-130 °C (decomp)(Solv: N,N-dimethylformamide (68-12-2); water (7732-18-5))
• 沸点：
  343.6±27.0 °C(Predicted)
• 密度：
  1.431±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-fluoro-2(1H)-quinolinone 在 正丁基锂 、 三溴氧磷 作用下， 以 乙醚 、 正己烷 为溶剂， 反应 1.25h， 生成 3-氟-2-喹啉羧酸
  参考文献：
  名称：

  Metalation/functionalization sequences applied to 2-bromo-3-fluoroquinolines

  摘要：

  Mono- and disubstituted 2-bromo-3-fluoroquinotines 3 are readily accessible. They can be converted into the 3-fluoroquinoline-2-carboxylic acids 5 by consecutive halogen/metal permutation and into the 2-bromo-3-fluoroquinoline-4-carboxylic acids 6 by consecutive deprotonation and carboxylation. The latter compounds can be reduced to afford the 3-fluoroquinoline-4-carboxylic acids 7. The yields are excellent throughout. Rather than to introduce one functional group alternatively at the 2- or 4-position, one may also attach two different functional groups sequentially to both sites. (C) 2004 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2004.10.053

文献信息

• JPH08208614A
  申请人：——

  公开号：JPH08208614A

  公开（公告）日：1996-08-13
• JPH08208617A
  申请人：——

  公开号：JPH08208617A

  公开（公告）日：1996-08-13
• SILICON NANOCARRIER FOR DELIVERY OF DRUG, PESTICIDES AND HERBICIDES , AND FOR WASTE WATER TREATMENT
  申请人：Sardari Lodriche Soroush

  公开号：US20130225412A1

  公开（公告）日：2013-08-29

  The various embodiments herein provide a nano silicon carrier as a drug delivery mechanism. The nano silicon carrier comprises a diatom frustules loaded with a drug molecule to be released at the target site. The diatom frustules are of Hannaea arcus and Navicula inflexa species of diatom. The pore size of the diatom frustules is 1 to 100 nm. The diatom frustules are comb-like in structure. The diatom frustules are in the form of powdered diatomaceous earth. The drug delivery mechanism described in the embodiments herein is a controlled release mechanism. The nano silicon carrier described in the embodiments herein is also used for delivery of pesticides and herbicides in plants. The nano silicon carrier described in the embodiments herein is also used in hormone waste water treatment.
• US5442070A
  申请人：——

  公开号：US5442070A

  公开（公告）日：1995-08-15
• US5874608A
  申请人：——

  公开号：US5874608A

  公开（公告）日：1999-02-23