3-氧代-4,5,6,7-四氢-[1,2]恶唑并[4,5-c]吡啶-4-羧酸 | 105701-66-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 3-氧代-4,5,6,7-四氢-[1,2]恶唑并[4,5-c]吡啶-4-羧酸
• 英文名称: (RS)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo<4,5-c>pyridine-4-carboxylic acid zwitterion
• 英文别名: (RS)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo<4,5-c>pyridine-4-carboxylic acid；3-Hydroxy-4,5,6,7-tetrahydro-isoxazolo(4,5-c)pyridine-4-carboxylic acid；3-oxo-4,5,6,7-tetrahydro-[1,2]oxazolo[4,5-c]pyridine-4-carboxylic acid
• CAS: 105701-66-4
• 化学式: C₇H₈N₂O₄
• 分子量: 184.152
• InChiKey: DBCBPNMITMFFKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  87.7
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 海关编码：
  2934999090

反应信息

• 作为产物：
  描述：

  (RS)-methyl 3-methoxy-5-nitroso-4,5,6,7-tetrahydroisoxazolo<4,5-c>pyridine-4-carboxylate 在 水 、 氢溴酸 、 溶剂黄146 、 三乙胺 作用下， 以 溶剂黄146 为溶剂， 反应 21.0h， 生成 3-氧代-4,5,6,7-四氢-[1,2]恶唑并[4,5-c]吡啶-4-羧酸
  参考文献：
  名称：

  Madsen; Schaumburg; Brehm, Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1986, vol. 40, # 2, p. 92 - 97

  摘要：

  DOI：

文献信息

• MADSEN, ULF;FERKANY, JOHN W.;JONES, BRUCE E.;EBERT, BJARKE;JOHANSEN, TOMM+, EUR. J. PHARMACOL. MOL. PHARMACOL. SECT., 189,(1990) N, C. 381-391
  作者：MADSEN, ULF、FERKANY, JOHN W.、JONES, BRUCE E.、EBERT, BJARKE、JOHANSEN, TOMM+

  DOI：——

  日期：——
• Novel Neuroprotective Compounds and Uses Thereof
  申请人：Gozin Michael

  公开号：US20100144868A1

  公开（公告）日：2010-06-10

  Disclosed are novel hybrid compounds having a fullerene core residue, one or more bioavailability enhancing moieties and one or more glutamate receptor ligand residues, whereby the bioavailability enhancing moiety allow the compound to reach an effective concentration in physiological media and pass the blood-brain barrier, as defined in the specification. Also disclosed are pharmaceutical compositions containing these hybrid compounds and uses thereof as antioxidants and/or neuroprotective agents for the treatment of medical conditions associated with oxidative stress and/or neural damage, such as, for example, neurological diseases, disorders and trauma, and hence in the treatment of CNS-associated diseases, disorders and trauma, as well as to uses thereof as antiviral, antibacterial, antiglycemic, antiarrhythmic, antidepressant and antitumor agents.
• Madsen; Schaumburg; Brehm, Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1986, vol. 40, # 2, p. 92 - 97
  作者：Madsen、Schaumburg、Brehm、Curtis、Krogsgaard-Larsen

  DOI：——

  日期：——