2-phenylethyl-6-propyl-2,3-dihydro-4H-pyran-4-one | 651738-91-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 2-phenylethyl-6-propyl-2,3-dihydro-4H-pyran-4-one
• 英文别名: 2-(2-Phenylethyl)-6-propyl-2,3-dihydro-4H-pyran-4-one；2-(2-phenylethyl)-6-propyl-2,3-dihydropyran-4-one
• CAS: 651738-91-9
• 化学式: C₁₆H₂₀O₂
• 分子量: 244.334
• InChiKey: COJQRWJDGZVELJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  反式-3-庚烯-2-酮 在 palladium dichloride disodium hydrogenphosphate 、 正丁基锂 、 氧气 、 二异丙胺 、 copper(l) chloride 作用下， 以 四氢呋喃 、 乙二醇二甲醚 、 正己烷 为溶剂， 反应 20.5h， 生成 2-phenylethyl-6-propyl-2,3-dihydro-4H-pyran-4-one
  参考文献：
  名称：

  Oxidative Cyclization of β-Hydroxyenones with Palladium(II):  A Novel Entry to 2,3-Dihydro-4H-pyran-4-ones

  摘要：

  A palladium(II)-mediated oxidative cyclization was found to be effective for the preparation of structurally diverse 2,3-dihydro-4H-pyran-4-ones from the corresponding beta-hydroxyenones. Attractive features of this transformation include the ready availability of the starting enones, the regiocontrol, and the easy access of enantiopure 2,3-dihydro-4H-pyran-4-one from the corresponding enantiopure enone.

  DOI：

  10.1021/ol0361296

文献信息

• Oxidative Cyclization of β-Hydroxyenones with Palladium(II):  A Novel Entry to 2,3-Dihydro-4<i>H</i>-pyran-4-ones
  作者：Maud Reiter、Sandrine Ropp、Véronique Gouverneur

  DOI：10.1021/ol0361296

  日期：2004.1.1

  A palladium(II)-mediated oxidative cyclization was found to be effective for the preparation of structurally diverse 2,3-dihydro-4H-pyran-4-ones from the corresponding beta-hydroxyenones. Attractive features of this transformation include the ready availability of the starting enones, the regiocontrol, and the easy access of enantiopure 2,3-dihydro-4H-pyran-4-one from the corresponding enantiopure enone.