There is disclosed a pharmaceutical composition comprising 1-(5-oxohexyl)-3-methylxanthine in admixture with a pharmaceutically acceptable excipient, wherein the pharmaceutical composition is useful for treating an immune disorder. There is also disclosed a method to modulate the response of a target cell to a stimulus, which method comprises contacting said cell with an amount of 1-(5-oxohexyl)-3-methylxanthine or a pharmaceutical composition thereof, wherein said amount effects a diminution in elevated levels of unsaturated, non-arachidonate phosphatidic acid (PA) and diacylglycerol (DAG) derived from said PA in said cells wherein said elevated levels are stimulated by an agent capable of elevating levels of said PA and said DAG, said diminution being equal to or greater than the diminution effected by treating said cells with pentoxifylline (PTX) at a concentration of 0.5 mmol, thereby modulating the response of said target cell.
本发明涉及一种制备成分为1-(5-氧代己基)-
3-甲基黄嘌呤与药用助剂混合物的药物组合物,该药物组合物可用于治疗免疫性疾病。本发明还涉及一种调节靶细胞对刺激的反应的方法,该方法包括将所述细胞与1-(5-氧代己基)-
3-甲基黄嘌呤或其药物组合物接触,其中所述剂量可使得细胞中不饱和的非
花生四烯酸磷脂酸(PA)和二酰基
甘油(
DAG)
水平下降,而这些
水平是由于能够提高所述PA和所述
DAG
水平的药物刺激所刺激的,所述下降效果等于或大于使用0.5mmol浓度的戊三酰四甲基
黄嘌呤(
PTX)处理所述细胞所产生的下降效果,从而调节所述靶细胞的反应。