[EN] ANTI-CD74 ANTIBODY CONJUGATES, COMPOSITIONS COMPRISING ANTI-CD74 ANTIBODY CONJUGATES AND METHODS OF USING ANTI-CD74 ANTIBODY CONJUGATES<br/>[FR] CONJUGUÉS D'ANTICORPS ANTI-CD74, COMPOSITIONS COMPRENANT DES CONJUGUÉS D'ANTICORPS ANTI-CD74 ET MÉTHODES D'UTILISATIONS DESDITS CONJUGUÉS D'ANTICORPS ANTI-CD74
申请人:SUTRO BIOPHARMA INC
公开号:WO2017132615A1
公开(公告)日:2017-08-03
Provided herein are antibody conjugates with binding specificity for CD74, wherein the antibody comprises a non-natural amino acid at a site selected from the group consisting of HC-F404, HC-K121, HC-Y180, HC-F241, HC-221, LC-T22, LC-S7, LC-N152, LC-K42, LC-E161, LC-D170, HC-S136, HC-S25, HC-A40, HC-S119, HC-S190, HC-K222, HC-R19, HC-Y52, or HC-S70, according to the Kabat, Chothia, or EU numbering scheme, and compositions comprising the antibody conjugates, including pharmaceutical compositions, methods of producing the conjugates, and methods of using the conjugates and compositions for therapy.