Propyl 4-hydroxycyclohexane-1-carboxylate | 116118-44-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Propyl 4-hydroxycyclohexane-1-carboxylate
• 英文别名: propyl 4-hydroxycyclohexane-1-carboxylate
• CAS: 116118-44-6
• 化学式: C₁₀H₁₈O₃
• 分子量: 186.25
• InChiKey: PGSHKRZDHRICCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS<br/>[FR] PYRAZOLOAZÉPIN-4-ONES SUBSTITUÉES ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE PHOSPHODIESTÉRASE
  申请人：LEO PHARMA AS

  公开号：WO2018108230A1

  公开（公告）日：2018-06-21

  The present invention relates to novel substituted pyrazoloazepin-4-ones with phosphodiesterase inhibitory activity, as well as to their use as therapeutic agents in the treatment of inflammatory diseases and conditions.

  本发明涉及具有磷酸二酯酶抑制活性的新型取代吡唑啉-4-酮化合物，以及它们作为治疗炎症性疾病和症状的治疗剂的用途。
• USE OF CYCLOHEXANOL DERIVATIVES AS ANTIMICROBIAL ACTIVE COMPOUNDS
  申请人：MERCK PATENT GMBH

  公开号：US20140335029A1

  公开（公告）日：2014-11-13

  The present invention relates to the use of at least one cyclohexanol derivative of the formula (I) and/or (II) as antimicrobial active compound or as anti-acne, antidandruff, antiperspirant or deodorant active compound, to preparations comprising these compounds, and to specific cyclohexanol derivatives and to a process for the preparation thereof.

  本发明涉及使用至少一种公式（I）和/或（II）的环己醇衍生物作为抗微生物活性化合物或抗痤疮、抗头皮屑、抗汗剂或除臭剂活性化合物，以及包含这些化合物的制剂，以及特定的环己醇衍生物和其制备方法。
• Triazole ACC inhibitors and uses thereof
  申请人：Gilead Apollo, LLC

  公开号：US10800791B2

  公开（公告）日：2020-10-13

  The present invention provides triazole compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

  本发明提供了可用作乙酰辅酶羧化酶（ACC）抑制剂的三唑化合物、其组合物以及使用方法。
• SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS
  申请人：Leo Pharma A/S

  公开号：EP3551633A1

  公开（公告）日：2019-10-16
• GEL FOR TOPICAL APPLICATION OF CLOVE ESSENTIAL OIL WITH BROAD SPECTRUM ANTI-INFLAMMATORY ACTION AND METHOD OF PREPARING SAME
  申请人：Cavallaro Antonino

  公开号：US20150182578A1

  公开（公告）日：2015-07-02

  A gel for topical application of clove essential oil with broad spectrum anti-inflammatory and analgesic action disclosed containing by weight of the total composition of: 30.0% of deionized water; 0.3% of acrylates/C10-30 alkyl acrylate crosspolymer; 0.1% of glycerin; 0.2% 0.2% of triethanolamine, 0.1% of tocopherol acetate; 0.5% of fragrance; 5% of clove essential oil; 2% of black pepper essential oil; 61.4% of isopropyl alcohol SDA; at least 0.1% of aloe barbadensis leaf extract; 0.2% of parabens mixture; the parabens mixture further comprising of 3% propylparaben, 11% methylparaben, and 30% diazolidinyl; and at least 0.1% (w) of ethylenediamine tetraacetic acid; and the method of preparation of said gel therein.