3,6,9,12,15-Pentaoxaheptadecane-1,17-diol, dimethanesulfonate | 109789-40-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol, dimethanesulfonate
• 英文别名: 2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol;methanesulfonic acid
• CAS: 109789-40-4
• 化学式: C14H34O13S2
• 分子量: 474.5
• InChiKey: QSYFPOQWVUPKJM-UHFFFAOYSA-N

物化性质

• 沸点：
  587.2±50.0 °C(Predicted)
• 密度：
  1.266±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.94
• 重原子数：
  29
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  212
• 氢给体数：
  4
• 氢受体数：
  13

文献信息

• Acridinium ester labels having hydrophilic modifiers
  申请人：——

  公开号：US20030045716A1

  公开（公告）日：2003-03-06

  The present invention is generally directed to detectable chemiluminescent acridinium ester labels having hydrophilic modifiers; to compositions, complexes and/or conjugates which include such labels; and to processes for performing bioanalytical assays for target analytes which use such labels. Assays for folate, theophylline, and tobramycin (using such labels with hydrophilic modifiers such as nonionic polyethylene glycol and polyionic spermine disulfonate and polyionic spermine dicarboxylate) are described in detail.

  本发明通常涉及具有亲水性修饰剂的可检测化学发光吖啶酯标记物；包括这种标记物的组合物、复合物和/或共轭物；以及使用这种标记物进行目标分析物的生物分析测定的过程。详细描述了使用具有亲水性修饰剂（如非离子聚乙二醇和聚离子精胺二磺酸盐和聚离子精胺二羧酸盐）的这种标记物进行叶酸、茶碱和托布拉霉素的测定。
• Flavonoid Dimers and Methods of Making and Using Such
  申请人：Chan Tak-Hang

  公开号：US20090197943A1

  公开（公告）日：2009-08-06

  Multidrug resistance (MDR) is a major problem in cancer chemotherapy. The best characterized resistance mechanism is the one mediated by the over-expression of drug efflux transporters, permeability-glycoprotein (P-gp), which pump a variety of anticancer drugs out of the cells, resulting in lowered intracellular drug accumulation. A series of flavonoid dimers are developed in this invention, which are linked together by linker groups of various lengths. These flavonoid dimers are found to be efficient P-gp modulators that increase cytotoxicity of anticancer drugs in vitro and dramatically enhance their intracellular drug accumulation. It is found that the flavonoid dimers of this invention is also useful in reducing drug resistance in treating parasitic diseases.

  多药耐药性（MDR）是癌症化疗中的主要问题。最好表征的耐药机制是通过过度表达药物外流转运蛋白、渗透性糖蛋白（P-gp）介导的耐药机制，它将各种抗癌药物泵出细胞，导致细胞内药物积累降低。本发明开发了一系列由不同长度的连接基团连接在一起的类黄酮二聚体。发现这些类黄酮二聚体是有效的P-gp调节剂，可以增加抗癌药物在体外的细胞毒性并显著提高它们的细胞内药物积累。同时，发现本发明的类黄酮二聚体也有助于减少治疗寄生虫病的耐药性。
• EP1273917B1
  申请人：——

  公开号：EP1273917B1

  公开（公告）日：2014-05-07
• FLAVONOID DIMERS AND METHODS OF MAKING AND USING SUCH
  申请人：The Hong Kong Polytechnic University

  公开号：EP2029568A1

  公开（公告）日：2009-03-04
• US6664043B2
  申请人：——

  公开号：US6664043B2

  公开（公告）日：2003-12-16