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3-氯-2,2,3-三氟丙酸 | 425-97-8

中文名称
3-氯-2,2,3-三氟丙酸
中文别名
7-溴-5-氯喹啉-醇
英文名称
3-chloro-2,2,3-trifluoro-propionic acid
英文别名
3-Chlor-2,2,3-trifluor-propionsaeure;3-Chloro-2,2,3-trifluoropropanoic acid
3-氯-2,2,3-三氟丙酸化学式
CAS
425-97-8
化学式
C3H2ClF3O2
mdl
——
分子量
162.496
InChiKey
IIJWIPPCXINBOZ-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    1.6
  • 重原子数:
    9
  • 可旋转键数:
    2
  • 环数:
    0.0
  • sp3杂化的碳原子比例:
    0.67
  • 拓扑面积:
    37.3
  • 氢给体数:
    1
  • 氢受体数:
    5

安全信息

  • 海关编码:
    2915900090

SDS

SDS:3bbd79562acb63ce8d49809ebd972c14
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上下游信息

  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量
    3,3-二氯-2,2,3-三氟-丙酸 3,3-dichloro-2,2,3-trifluoro-propionic acid 2358-51-2 C3HCl2F3O2 196.941

反应信息

  • 作为反应物:
    参考文献:
    名称:
    Fluorocarboxylic Acids and Amides from Fluoroölefins and Sodium Cyanide
    摘要:
    DOI:
    10.1021/ja01556a067
  • 作为产物:
    描述:
    三氟氯乙烯氰化钠oxonium 作用下, 以 乙腈 为溶剂, 生成 3-氯-2,2,3-三氟丙酸
    参考文献:
    名称:
    Halogenated Diazirines as Photolabel Mimics of the Inhaled Haloalkane Anesthetics
    摘要:
    The inhaled anesthetics are low affinity volatile compounds whose mechanism of action remains unclear, in part due to the difficulty of determining their binding targets. Photolabeling may help resolve this difficulty, and thus we have synthesized six compounds (four previously unreported) with structural and physical similarity to halothane (1-bromo-1-chloro-2,2,2-trifluoroethane), a commonly used clinical anesthetic. These compounds incorporate either a diazo, diazirine, or azido group to provide photolability in the long-UV range and to provide a highly reactive photolysis product. While several of the compounds have immobilizing activity in tadpoles, it is complicated by either toxicity or very low potency. One compound however, a halogenated three-carbon diazirine 4, is a potent anesthetic, is apparently nontoxic, potentiates GABA(A) Cl- currents, and stabilizes serum albumin, all of which are features of halothane. When tagged with radioactivity, this compound should serve as a reasonable probe of haloalkane anesthetic binding targets and sites.
    DOI:
    10.1021/jm0104926
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文献信息

  • Photographic elements containing cyan-forming couplers
    申请人:Agfa-Gevaert, N.V.
    公开号:US04341864A1
    公开(公告)日:1982-07-27
    Cyan-forming color couplers according to the formula: ##STR1## wherein Z is hydrogen in the case of 4-equivalent couplers or a substituent that splits off upon color development, thus conferring a 2-equivalent character to the color coupler, and Y is a ballasting group. These cyan-forming color couplers can be incorporated in (a) red-sensitized silver halide emulsion layer(s) of a photographic multilayer color element or in a non-light-sensitive colloid layer in water-permeable relationship with the red-sensitized emulsion layer(s).
    根据以下公式制备青色形成的色偶:##STR1## 其中,在4当量色偶的情况下,Z是氢,或者是在颜色发展时脱离的取代基,从而赋予色偶2当量特性,而Y是一个负载基团。这些青色形成的色偶可以被纳入(a)感光红敏银卤化物乳剂层的多层照相彩色元素中或者在与红敏乳剂层(s)具有水透过性的非感光胶体层中。
  • England; Melby, <1973>239
    作者:England、Melby
    DOI:——
    日期:——
  • Halogenated Diazirines as Photolabel Mimics of the Inhaled Haloalkane Anesthetics
    作者:Roderic G. Eckenhoff、Frank J. Knoll、Eric P. Greenblatt、William P. Dailey
    DOI:10.1021/jm0104926
    日期:2002.4.1
    The inhaled anesthetics are low affinity volatile compounds whose mechanism of action remains unclear, in part due to the difficulty of determining their binding targets. Photolabeling may help resolve this difficulty, and thus we have synthesized six compounds (four previously unreported) with structural and physical similarity to halothane (1-bromo-1-chloro-2,2,2-trifluoroethane), a commonly used clinical anesthetic. These compounds incorporate either a diazo, diazirine, or azido group to provide photolability in the long-UV range and to provide a highly reactive photolysis product. While several of the compounds have immobilizing activity in tadpoles, it is complicated by either toxicity or very low potency. One compound however, a halogenated three-carbon diazirine 4, is a potent anesthetic, is apparently nontoxic, potentiates GABA(A) Cl- currents, and stabilizes serum albumin, all of which are features of halothane. When tagged with radioactivity, this compound should serve as a reasonable probe of haloalkane anesthetic binding targets and sites.
  • Fluorocarboxylic Acids and Amides from Fluoroölefins and Sodium Cyanide
    作者:D. C. England、R. V. Lindsey、L. R. Melby
    DOI:10.1021/ja01556a067
    日期:1958.12
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