7-(Propan-2-yl)-1,4-dioxaspiro[4.4]nonane | 88438-14-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 7-(Propan-2-yl)-1,4-dioxaspiro[4.4]nonane
• 英文别名: 8-propan-2-yl-1,4-dioxaspiro[4.4]nonane
• CAS: 88438-14-6
• 化学式: C₁₀H₁₈O₂
• 分子量: 170.25
• InChiKey: JBMJDAUVYRXLNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• STEROID DERIVATIVE REGULATORS, METHOD FOR PREPARING THE SAME, AND USES THEREOF
  申请人：JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD.

  公开号：US20210139530A1

  公开（公告）日：2021-05-13

  Steroid derivative regulators, a method for preparing the same, and uses thereof are described. Specifically, a compound of formula (I), a preparation method therefor, a pharmaceutical composition containing the compound, and uses thereof as a regulator the of GABA A receptor for treating depression, convulsion, Parkinson's disease, and nervous system diseases are described, wherein the substituents of the formula (I) are as defined in the description.
• NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE REGULATOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
  申请人：SHANGHAI HANSOH BIOMEDICAL CO., LTD.

  公开号：US20220213100A1

  公开（公告）日：2022-07-07

  Disclosed are a nitrogen-containing heterocyclic derivative regulator, a preparation method therefor and an application thereof. In particular, disclosed are a compound as represented by general formula (I), a preparation method for the compound and a pharmaceutical composition containing the compound, and the use thereof as a KRAS G12C mutation inhibitor in treatment of diseases or symptoms such as leukemia, neuroblastoma, melanoma, breast cancer, lung cancer and colon cancer, wherein the definitions of substituents in general formula (I) are the same as those in the description.