3-氯-2-羟基-2-甲基-丙酸 | 13881-41-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 中文名称: 3-氯-2-羟基-2-甲基-丙酸
• 英文名称: 3-chloro-2-methyl-2-hydroxypropionic acid
• 英文别名: 2-hydroxy-2-methyl-3-chloropropionic acid；β-chloro-α-hydroxy-isobutyric acid；β-Chlor-α-hydroxy-isobuttersaeure；3-Chlor-2-methyl-propanol-(2)-saeure-(1)；3-chloro-2-hydroxy-2-methyl propionic acid；α-Hydroxy-β-chlor-isobuttersaeure；3-chloro-2-hydroxy-2-methylpropanoic acid
• CAS: 13881-41-9
• 化学式: C₄H₇ClO₃
• mdl: MFCD19228086
• 分子量: 138.551
• InChiKey: NFSVYGUHJOOEJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2918199090

反应信息

• 作为反应物：
  描述：

  3-氯-2-羟基-2-甲基-丙酸 在 氯化亚砜 作用下， 生成 β-Chlor-α-hydroxy-α-methyl-propionsaeure-anhydrosulfit
  参考文献：
  名称：

  Notes

  摘要：

  DOI：

  10.1039/jr9650000786
• 作为产物：
  描述：

  β-chloro-α-hydroxy-isobutyronitrile 在 盐酸 作用下， 生成 3-氯-2-羟基-2-甲基-丙酸
  参考文献：
  名称：

  HEALTH PROMOTING CONSTITUENTS IN PLANT DERIVED EDIBLE OILS

  摘要：

  ABSTRACTOf all the edible oils, only that produced from olives has had its health attributes studied in detail. For maximum nutritional benefit, an edible oil should contain minimal levels of saturated fats, especially lauric and myristic acids and minimal levels of trans fatty acids. If the oils are not to be heated repeatedly and if they contain high levels of antioxidants, they should contain omega‐3 and possibly omega‐6 polyunsaturated fatty acids. The fatty acid profile should be dominated by monounsaturated fatty acids. Secondary products which act as antioxidants including polyphenols, proanthocyanidins, tocopherols and carotenoids increase the shelf‐life of oils, reportedly reduce cardiovascular disease and provide some anticarcinogenic properties. More research is also required, but there is evidence that phytosterols and squalene are also beneficial components of edible oils. Selection and breeding can be used to increase the desirable components of edible oils. Geographic, culture and environmental factors can influence the properties of the oil produced by crops, and methods of processing can greatly reduce the levels of health promoting components. Despite the current anti‐GMO sentiments, biotechnology should be used both in the development of plant cultivars which produce nutritional oils and in processing to maximize the desirable components.

  DOI：

  10.1111/j.1745-4522.2002.tb00205.x

文献信息

• Process for the preparation of 3-¬(4-fluorophenyl) sulfonyl|-2-hydroxy-2-methyl propionic acid
  申请人：Helm AG

  公开号：EP1669347A1

  公开（公告）日：2006-06-14

  The present invention relates to a process for the preparation of 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropionic acid, which comprises the step of reacting 3-chloro-2-methyl-2-hydroxypropionic acid with a salt of 4-fluorophenylsulfinic acid, and the use of (+/-)- and (-)-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropionic acid and (+)-3-chloro-2-methyl-2-hydroxypropionic acid in the preparation of bicalutamide.

  本发明涉及一种制备3-[(4-氟苯基)磺酰基]-2-羟基-2-甲基丙酸的方法，包括将3-氯-2-甲基-2-羟基丙酸与4-氟苯基亚磺酸的盐反应的步骤，以及在比卡鲁胺的制备中使用(+/-)-和(-)-3-[(4-氟苯基)磺酰基]-2-羟基-2-甲基丙酸和(+)-3-氯-2-甲基-2-羟基丙酸。
• Reaction of dinitrogen trioxide with 2-methylpropene and other alkenes. Evidence for electrophilic nitrosation
  作者：James R. Park、D. Lyn H. Williams

  DOI：10.1039/p29760000828

  日期：——

  solid dimer product from the reaction of dinitrogen trioxide and 2-methylpropene was converted to the corresponding oxime by heating with or without a solvent for ca. 2 days. This establishes the orientation of the dinitrogen trioxide addition product as the 1-nitroso- rather than the 2-nitroso-compound as previously thought. A number of other alkene–dinitrogen trioxide adducts have been prepared; most

  将三氧化二氮与2-甲基丙烯反应得到的固体二聚体产物通过在有或没有溶剂的条件下加热约12小时而转化为相应的肟。2天。这确定了三氧化二氮加成产物的取向是1-亚硝基-而不是以前认为的2-亚硝基-化合物。还制备了许多其他的烯烃-三氧化二氮加合物。红外光谱表明，大多数以肟的形式部分存在，在升温或长时间放置后，肟的比例增加。两种加合物的水解得到的产物与建议的取向一致。在这些结果与其他研究人员发现的类似结果之间存在惊人的相似之处，他们研究了四氧化二氮与烯烃加成的产物及其水解产物。
• Bloomfield; Farmer; Hose, Journal of the Chemical Society, 1933, p. 801,805
  作者：Bloomfield、Farmer、Hose

  DOI：——

  日期：——
• Fourneau, Bulletin de la Societe Chimique de France, 1909, vol. <4>5, p. 241
  作者：Fourneau

  DOI：——

  日期：——
• Boguslavskaya,L.S. et al., Journal of Organic Chemistry USSR (English Translation), 1974, vol. 10, # 10, p. 2084 - 2089
  作者：Boguslavskaya,L.S. et al.

  DOI：——

  日期：——