1-[4-(2-Propen-1-yl)-3-pyridinyl]ethanone | 1211580-52-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[4-(2-Propen-1-yl)-3-pyridinyl]ethanone
• 英文别名: 1-(4-prop-2-enylpyridin-3-yl)ethanone
• CAS: 1211580-52-7
• 化学式: C₁₀H₁₁NO
• 分子量: 161.2
• InChiKey: QXRQDJDJTGQSLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] SUBSTITUTED 3-PYRIDYL PYRROLES AND 3-PYRIDYL PYRAZOLES AS C17,20 LYASE INHIBITORS<br/>[FR] 3-PYRIDYL PYRROLES ET 3-PYRIDYL PYRAZOLES SUBSTITUES EN TANT QU'INHIBITEURS DE LA LYASE C17,20
  申请人：BAYER AG

  公开号：WO2003027101A1

  公开（公告）日：2003-04-03

  The invention provides novel substituted 3-pyridyl pyrroles and 3-pyridyl pyrazoles and pharmaceutical compositions thereof. The invention also provides methods of use of substituted 3-pyridyl pyrroles and 3-pyridyl pyrazoles and pharmaceutical compositions thereof as inhibitors of lyases, e.g., the 17α-hydroxylase-C17,20 enzyme. The invention further provides methods for the treatment of cancer in a subject, comprising administering a substituted 3-pyridyl pyrroles and 3-pyridyl pyrazoles or a pharmaceutical composition comprising a substituted 3-pyridyl pyrroles and 3-pyridyl pyrazoles to a subject. The cancer can be, e.g., prostate cancer or breast cancer.