3-氯-6-丙基氨基吡嗪 | 951885-19-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 3-氯-6-丙基氨基吡嗪
• 英文名称: 6-Chloro-N-propylpyridazin-3-amine
• CAS: 951885-19-1
• 化学式: C₇H₁₀ClN₃
• mdl: MFCD09800940
• 分子量: 171.63
• InChiKey: QXJWIXPQOHPVFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  37.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090
• 包装等级：
  III
• 危险类别：
  6.1
• 危险性防范说明：
  P261,P264,P270,P271,P280,P302+P352,P304+P340,P310,P330,P361,P403+P233,P405,P501
• 危险品运输编号：
  2811
• 危险性描述：
  H301,H311,H331
• 储存条件：
  温度：2-8°C，保存环境：惰性气体

反应信息

• 作为反应物：
  描述：

  咪唑 、 3-氯-6-丙基氨基吡嗪 以56%的产率得到
  参考文献：
  名称：

  SIMAMURA, XIROSI;KOSEHGI, KODZI;YANAGINUMA, XIDEHYA

  摘要：

  DOI：
• 作为产物：
  描述：

  正丙胺 、 3,6-二氯哒嗪 在 三乙胺 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以91%的产率得到3-氯-6-丙基氨基吡嗪
  参考文献：
  名称：

  Selective mono-amination of dichlorodiazines

  摘要：

  A mild, easy-to-perform, and versatile method for the formation of aminochlorodiazines from reaction of several types of dichlorodiazines (i.e., pyridazines, pyrimidines, and pyrazines) with primary or secondary amines in ethanol in the presence of triethylamine as a base, is described. The methodology is general and efficient despite noticeable difference in reactivity between diazines. While dichloropyridazine and dichloropyrazine require several hours of heating at reflux for the reaction to proceed, dichloropyrimidines reach completion within minutes at room temperature. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.05.056

文献信息

• Selective mono-amination of dichlorodiazines
  作者：Stéphane Sengmany、Julie Lebre、Erwan Le Gall、Eric Léonel

  DOI：10.1016/j.tet.2015.05.056

  日期：2015.7

  A mild, easy-to-perform, and versatile method for the formation of aminochlorodiazines from reaction of several types of dichlorodiazines (i.e., pyridazines, pyrimidines, and pyrazines) with primary or secondary amines in ethanol in the presence of triethylamine as a base, is described. The methodology is general and efficient despite noticeable difference in reactivity between diazines. While dichloropyridazine and dichloropyrazine require several hours of heating at reflux for the reaction to proceed, dichloropyrimidines reach completion within minutes at room temperature. (C) 2015 Elsevier Ltd. All rights reserved.
• SIMAMURA, XIROSI;KOSEHGI, KODZI;YANAGINUMA, XIDEHYA
  作者：SIMAMURA, XIROSI、KOSEHGI, KODZI、YANAGINUMA, XIDEHYA

  DOI：——

  日期：——