ethyl (2-[2-(2-phenyl-1,3-thiazolo-4-carbonyl)-N-acetyl-hydrazino]-thiazol-4-yl)acetate | 1256585-83-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ethyl (2-[2-(2-phenyl-1,3-thiazolo-4-carbonyl)-N-acetyl-hydrazino]-thiazol-4-yl)acetate
• 英文别名: Ethyl 2-[2-[acetyl-[(2-phenyl-1,3-thiazole-4-carbonyl)amino]amino]-1,3-thiazol-4-yl]acetate
• CAS: 1256585-83-7
• 化学式: C₁₉H₁₈N₄O₄S₂
• 分子量: 430.508
• InChiKey: VQWPPFQHHYVIDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  158
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  ethyl (2-[2-(2-phenyl-1,3-thiazolo-4-carbonyl)-hydrazino]-thiazol-4-yl)acetate 、 乙酸酐 在 吡啶 作用下， 以58.63%的产率得到ethyl (2-[2-(2-phenyl-1,3-thiazolo-4-carbonyl)-N-acetyl-hydrazino]-thiazol-4-yl)acetate
  参考文献：
  名称：

  Synthesis of some p-toluenesulfonyl-hydrazinothiazoles and hydrazino-bis-thiazoles and their anticancer activity

  摘要：

  A series of novel p-toluenesulfonyl-hydrazinothiazoles and hydrazino-bis-thiazoles derivatives (2a-f,3a-f, and 5-8) were synthesized by initial condensation of p-toluenesulfonylthiosemicarbazide 1 with a series of alpha-halogenocarbonyls in acetone or dimethylformamide (DMF)/acetone, mixture. All our synthesized compounds were submitted for further acylation reaction in the presence of acetic anhydride. The structures of newly synthesized derivatives 2a-f, 3a-f and 5-8 were confirmed by IR, H-1-NMR, EIMS spectral data and elemental analysis. Compounds 2a, 2c, 2d, 2e and 3a showed significant anticancer activities (IC50 < 10 mu M) on both prostate DU-145 and hepatocarcinoma Hep-G2 cancer cell lines. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.08.017