3-氯丙基异丙基醚 | 72468-94-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3-氯丙基异丙基醚
• 中文别名: 1-氯-3-异丙氧基丙烷
• 英文名称: 1-Chloro-3-isopropoxypropane
• 英文别名: 1-chloro-3-propan-2-yloxypropane
• CAS: 72468-94-1
• 化学式: C₆H₁₃ClO
• mdl: MFCD09753651
• 分子量: 136.62
• InChiKey: OYVDATWIUMMRMU-UHFFFAOYSA-N

物化性质

• 沸点：
  144.0±13.0 °C(Predicted)
• 密度：
  0.937±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2909199090

文献信息

• [EN] 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES AS 5HT4-ANTAGONISTS<br/>[FR] 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES SERVANT D'ANTAGONISTES DE 5HT4
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2005000838A1

  公开（公告）日：2005-01-06

  The present invention is concerned with novel compounds of formula (I) having 5HT4-antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as the use as a medicine of said compounds.

  本发明涉及具有5HT4拮抗性质的式(I)的新化合物。该发明还涉及制备这种新化合物的方法，包括将该新化合物作为药物的药物组合物以及该化合物的药用用途。
• [EN] 5HT4-ANTAGONISTIC 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES<br/>[FR] 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES ANTAGONISTES DES RECEPTEURS 5HT4
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2005003122A1

  公开（公告）日：2005-01-13

  The present invention is concerned with novel compounds of formula (I) having 5HT4-antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as the use as a medicine of said compounds.

  本发明涉及具有5HT4拮抗性质的式(I)的新化合物。该发明还涉及制备这种新化合物的方法，包括该新化合物的药物组合物以及该化合物作为药物的用途。
• NOVEL COUMARIN DERIVATIVE HAVING ANTITUMOR ACTIVITY
  申请人：Iikura Hitoshi

  公开号：US20100004233A1

  公开（公告）日：2010-01-07

  The present invention provides a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof: wherein: X is selected from heteroaryl etc., Y 1 and Y 2 are selected from —N═ etc., Y 3 and Y 4 are selected from —CH═ etc., A is selected from sulfamide etc., R 1 is selected from hydrogen etc., and R 2 is selected from C 1-6 alkyl etc. The compound or salt has sufficiently high antitumor activity, and is useful in the treatment of cell proliferative disorders, particularly cancers. The present invention also provides a pharmaceutical composition containing the compound or salt as an active ingredient.

  本发明提供了一个由下式（1）所表示的化合物或其药学上可接受的盐： 其中，X选择自杂环芳基等，Y1和Y2选择自—N═等，Y3和Y4选择自—CH═等，A选择自磺酰胺等，R1选择自氢等，R2选择自C1-6烷基等。该化合物或盐具有足够高的抗肿瘤活性，并且在治疗细胞增殖性疾病，特别是癌症方面有用。本发明还提供了一种含有该化合物或盐作为活性成分的药物组合物。
• 4-(Aminomethyl)-piperidine benzamides as 5ht4 - antagonists
  申请人：Bosmans René Marie André Jean-Paul

  公开号：US20060281753A1

  公开（公告）日：2006-12-14

  The present invention is concerned with novel compounds of formula (I) having 5HT 4 -antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as the use as a medicine of said compounds.

  本发明涉及具有5HT4拮抗性质的式（I）新化合物。本发明还涉及制备这种新化合物的方法，包含这种新化合物的药物组合物以及这些化合物作为药物的用途。
• 5Ht4-antagonistic 4-(aminomethyl)-piperidine benzamides
  申请人：Bosmans Rene Marie Andre Jean-Paul

  公开号：US20070032486A1

  公开（公告）日：2007-02-08

  The present invention is concerned with novel compounds of formula (I) having 5HT 4 -antagonistic properties. The invention further relates to methods for preparing such novel compounds, pharmaceutical compositions comprising said novel compounds as well as the use as a medicine of said compounds.

  本发明涉及具有5HT4-拮抗性质的式（I）新化合物。本发明还涉及制备这种新化合物的方法、包含所述新化合物的药物组合物以及将所述化合物用作药物的用途。