O-(4-(2-oxotetrahydrofuran-3-yl)butyl)hydroxylammonium trifluoroacetate | 1101207-25-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: O-(4-(2-oxotetrahydrofuran-3-yl)butyl)hydroxylammonium trifluoroacetate
• CAS: 1101207-25-3
• 化学式: C₂HF₃O₂*C₈H₁₅NO₃
• 分子量: 287.236
• InChiKey: LITRLWNPJCEFSN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.24
• 重原子数：
  19.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  98.85
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  O-(4-(2-oxotetrahydrofuran-3-yl)butyl)hydroxylammonium trifluoroacetate 在 potassium carbonate 作用下， 以 甲醇 、 水 为溶剂， 反应 1.0h， 以74%的产率得到3-(4-(aminooxy)butyl)dihydrofuran-2(3H)-one
  参考文献：
  名称：

  A versatile radical based approach to O-alkylated hydroxylamines and oximes

  摘要：

  O-Alkylhydroxylamines, often used for the preparation of bioconjugates, can be readily obtained by radical addition to suitable O-alkenylhydroxylamine derivatives. In the case of N-Boc-O-allylhydroxylamine, the addition is unexpectedly followed by elimination resulting in an overall allylation of the radical species. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.08.113
• 作为产物：
  描述：

  tert-butyl 4-(2-oxotetrahydrofuran-3-yl)butoxycarbamate 、 三氟乙酸 以 二氯甲烷 为溶剂， 反应 0.58h， 以99%的产率得到O-(4-(2-oxotetrahydrofuran-3-yl)butyl)hydroxylammonium trifluoroacetate
  参考文献：
  名称：

  A versatile radical based approach to O-alkylated hydroxylamines and oximes

  摘要：

  O-Alkylhydroxylamines, often used for the preparation of bioconjugates, can be readily obtained by radical addition to suitable O-alkenylhydroxylamine derivatives. In the case of N-Boc-O-allylhydroxylamine, the addition is unexpectedly followed by elimination resulting in an overall allylation of the radical species. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.08.113