N-(3-Diethylsulfamoyl-4-methoxyphenyl)maleimide | 152904-13-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: N-(3-Diethylsulfamoyl-4-methoxyphenyl)maleimide
• 英文别名: 5-(2,5-dioxopyrrol-1-yl)-N,N-diethyl-2-methoxybenzenesulfonamide
• CAS: 152904-13-7
• 化学式: C₁₅H₁₈N₂O₅S
• 分子量: 338.384
• InChiKey: DIEPLGCSAWNBNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.16
• 重原子数：
  23.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  83.99
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  N-(3-Diethylsulfamoyl-4-methoxyphenyl)maleimide 在 sodium hydroxide 、 盐酸 作用下， 以 水 、 乙腈 为溶剂， 反应 3.0h， 以68%的产率得到(Z)-4-[3-(diethylsulfamoyl)-4-methoxyanilino]-4-oxobut-2-enoic acid
  参考文献：
  名称：

  CHLOROSULFONATION OFN-ARYLMALEIMIDES

  摘要：

  N-phenylmaleimides, o-, m- and p- substituted (1) reacted with excess chlorosulfonic acid to give the corresponding sulphonyl chlorides (2-5). These were condensed with amines and phenols to give derivatives (7-29) which underwent hydrolysis or ammonolysis to give respectively the sulfamoyl maleamic acids (31-34) and sulfamoyl maleamides (35-39).

  DOI：

  10.1080/10426509308034412
• 作为产物：
  描述：

  N-(4-甲氧基苯基)马来酸 在 氯磺酸 、 sodium acetate 、 乙酸酐 作用下， 以 乙醚 、 氯仿 、 乙腈 为溶剂， 反应 5.5h， 生成 N-(3-Diethylsulfamoyl-4-methoxyphenyl)maleimide
  参考文献：
  名称：

  CHLOROSULFONATION OFN-ARYLMALEIMIDES

  摘要：

  N-phenylmaleimides, o-, m- and p- substituted (1) reacted with excess chlorosulfonic acid to give the corresponding sulphonyl chlorides (2-5). These were condensed with amines and phenols to give derivatives (7-29) which underwent hydrolysis or ammonolysis to give respectively the sulfamoyl maleamic acids (31-34) and sulfamoyl maleamides (35-39).

  DOI：

  10.1080/10426509308034412

文献信息

• Synthesis of Di- and Tetra-Sulfonated Heterocyclic Compounds by Crisscross Cycloaddition Reactions
  作者：Augusto C. Tomé、José A. S. Cavaleiro、Fernando M. J. Domingues、Richard J. Cremlyn

  DOI：10.1080/104265090930362

  日期：2005.12

  Using sulfonated diaryl azines and sulfonated N-arylmaleimides as starting reagents, a range of di- and tetra-sulfonated crisscross cycloadducts were selectively prepared. While the di-sulfonated adducts were obtained by carrying out the cycloaddition reaction in solution, the tetra-sulfonated adducts could be obtained only by fusion of the two reagents in the absence of solvent. The stereoisomers of the sulfonated cycloadducts were separated by preparative TLC.
• Tome, Augusto C.; Cavaleiro, Jose A. S.; Domingues, Fernando M. J., Phosphorus, Sulfur and Silicon and the Related Elements, 1993, vol. 79, # 1,4, p. 187 - 194
  作者：Tome, Augusto C.、Cavaleiro, Jose A. S.、Domingues, Fernando M. J.、Cremlyn, Richard J.

  DOI：——

  日期：——