γ-glutamyl-γ-glutamyl-methionine | 41515-84-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: γ-glutamyl-γ-glutamyl-methionine
• 英文别名: gamma-Glutamyl-gamma-glutamylmethionine；(2S)-2-amino-5-[[(1S)-1-carboxy-4-[[(1S)-1-carboxy-3-methylsulfanylpropyl]amino]-4-oxobutyl]amino]-5-oxopentanoic acid
• CAS: 41515-84-8
• 化学式: C₁₅H₂₅N₃O₈S
• 分子量: 407.445
• InChiKey: OGZNUDJBIAOLAA-GUBZILKMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.9
• 重原子数：
  27
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  221
• 氢给体数：
  6
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  L-蛋氨酸 、 L-谷氨酰胺 在 γ-glutamyltransferase from Escherichia coli T413L mutant 、 sodium hydroxide 作用下， 以 水 为溶剂， 以47 %的产率得到L-gamma-谷氨酰-L-蛋氨酸
  参考文献：
  名称：

  突变型大肠杆菌γ-谷氨酰转移酶催化的γ-谷氨酰二肽的酶促合成

  摘要：

  在大肠杆菌γ-谷氨酰转移酶的活性位点内鉴定出两个残基，推测与受体底物结合有关。这些残基的点突变提供了两种催化特性改变的突变酶。突变体 T413L 显示出非常有希望的高达 20:1 的转肽水解比。这两个突变体被测试为用于酶促合成具有增味特性的 γ-谷氨酰二肽的生物催化剂。

  DOI：

  10.1002/ejoc.202200907

文献信息

• [EN] BIOMARKERS RELATED TO ORGAN FUNCTION<br/>[FR] BIOMARQUEURS LIÉS À LA FONCTION D'UN ORGANE
  申请人：UNIV PITTSBURGH

  公开号：WO2015042602A1

  公开（公告）日：2015-03-26

  Disclosed herein are methods of identifying biomarkers (such as genes (e.g., RNA or mRNA), proteins, and/or small molecules) that can be used to predict organ or tissue function or dysfunction. In some embodiments, the methods include ex vivo perfusion of the organ or tissue, collection of samples from the organ or tissue (for example, perfusate, fluids produced by the organ (such as bile or urine), or tissue biopsies) and measuring the level of one or more biomarkers in the sample. It is also disclosed herein that an analysis of biomarkers (such as genes (e.g., RNA or mRNA), proteins, and/or small molecules) present in a biological sample from an organ, tissue, or subject can be used to identify whether the organ, tissue, or subject is at risk for (or has) organ dysfunction or organ failure.
• Enzymatic Synthesis of γ‐Glutamyl Dipeptides Catalysed by Mutant <i>E. coli</i> γ‐Glutamyltransferases
  作者：Marco Rabuffetti、Giovanna Speranza、Cinzia Calvio、Carlo F. Morelli

  DOI：10.1002/ejoc.202200907

  日期：2022.11.18

  identified inside the active site of E. coli γ-glutamyltransferase, putatively involved in acceptor substrate binding. Point-mutation of these residues afforded two mutant enzymes with altered catalytic properties. Mutant T413L showed a very promising transpeptidation-to-hydrolysis ratio up to 20 : 1. The two mutants were tested as biocatalysts for the enzymatic synthesis of γ-glutamyl dipeptides with flavor-enhancer

  在大肠杆菌γ-谷氨酰转移酶的活性位点内鉴定出两个残基，推测与受体底物结合有关。这些残基的点突变提供了两种催化特性改变的突变酶。突变体 T413L 显示出非常有希望的高达 20:1 的转肽水解比。这两个突变体被测试为用于酶促合成具有增味特性的 γ-谷氨酰二肽的生物催化剂。