2-bromoethoxymethoxyethane | 15495-78-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-bromoethoxymethoxyethane
• 英文别名: 1-Bromo-2-(ethoxymethoxy)ethane
• CAS: 15495-78-0
• 化学式: C₅H₁₁BrO₂
• 分子量: 183.045
• InChiKey: FPHSEBHPKKKYKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  8
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-CBz-L-homocysteine 、 2-bromoethoxymethoxyethane 在 sodium hydroxide 、 盐酸 作用下， 以 水 为溶剂， 反应 2.0h， 以98%的产率得到N-CBz-S-(2-(2-methoxyethoxy)ethyl)-L-homocysteine
  参考文献：
  名称：

  Multimodal Switching of Conformation and Solubility in Homocysteine Derived Polypeptides

  摘要：

  We report the design and synthesis of poly(S-alkyl-L-homocysteine)s, which were found to be a new class of readily prepared, multiresponsive polymers that possess the unprecedented ability to respond in different ways to different stimuli, either through a change in chain conformation or in water solubility. The responsive properties of these materials are also effected under mild conditions and are completely reversible for all pathways. The key components of these polymers are the incorporation of water solubilizing alkyl functional groups that are integrated with precisely positioned, multiresponsive thioether linkages. This promising system allows multimodal switching of polypeptide properties to obtain desirable features, such as coupled responses to multiple external inputs.

  DOI：

  10.1021/ja500372u