| 894075-80-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 894075-80-0
• 化学式: C₄₄H₇₆N₄O₃₁
• 分子量: 1157.1
• InChiKey: XIRVDQHKJHPTRH-VYUOUSLUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -13.69
• 重原子数：
  79.0
• 可旋转键数：
  22.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  547.76
• 氢给体数：
  20.0
• 氢受体数：
  32.0

反应信息

• 作为产物：
  描述：

  在 盐酸 、 Campylobacter jejuni UDP-Glc/GlcNAc-4'-epimerase 、 human His6-propeptide-placental catβ1,4-galactosyltransferase 1 fusion protein 作用下， 以 水 为溶剂， 生成
  参考文献：
  名称：

  Chemo-enzymatic synthesis of functionalized oligomers of N-acetyllactosamine glycan derivatives and their immobilization on biomaterial surfaces

  摘要：

  Poly-N-acetyllactosamines (poly-LacNAc, [-3Gal(beta 1-4)GlcNAc(beta 1-](n)) are terminal glycan structures present in glycoproteins and glycolipids. Their biological functions as ligands for galectins and as carriers of glycan epitopes are well documented. In the present paper we have characterized six novel functionalized beta-D-GlcNAc derivatives, including aglyca of varying hydrophobicity and molecular weight, as substrates for recombinant human beta 1,4 galactosyltransferase 1 (beta 4GalT-1). The sugar derivatives carry short or long amino- or azide-terminated linker molecules for further modification or immobilization. The linker chemistry had an impact on enzyme kinetics and enzymatic syntheses of N-acetyllactosamine derivatives (LacNAc, Gal(beta 1-4)GlcNAc(beta 1-R). The combination of beta 4GaIT-1 with bacterial beta 1,3-N-acetylglucosaminyltransferase (beta 3GlcNAc-T) resulted in the preparative syntheses of LacNAc oligomers with up to three LacNAc repeating units. All products were characterized by NMR and MS. The obtained LacNAc glycans were immobilized onto microtiter plates and their efficiency of binding of fungal galectin CGL2 was determined. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcatb.2012.02.002