3-chloro-6-phenyl-11H-benzo[b][1,4]benzodiazepine | 1447840-11-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 3-chloro-6-phenyl-11H-benzo[b][1,4]benzodiazepine
• CAS: 1447840-11-0
• 化学式: C₁₉H₁₃ClN₂
• 分子量: 304.779
• InChiKey: NAZHHCCSOLLVLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(4-chloro-2-nitro-anilino)-benzophenone 在 palladium 10% on activated carbon 、 氢气 、 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 反应 0.58h， 生成 3-chloro-6-phenyl-11H-benzo[b][1,4]benzodiazepine
  参考文献：
  名称：

  An efficient synthesis of substituted 1,4-diazepines by a Pd catalyzed amination and sequential hydrogenation condensation

  摘要：

  An efficient synthesis of substituted 1,4-diazepines is developed. The accessible intermediates have been obtained via Pd-catalyzed amination. The subsequent hydrogenation and intramolecular condensation sequences could be conducted successively in one pot without special operation. The mild and general strategy enables the synthesis of various substituted 1,4-diazepines in high yields. (C) 2013 Da-Li Yin. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2013.04.028

文献信息

• Iron catalyzed cross-coupling reactions of imidoyl derivatives
  申请人：Olsson Roger

  公开号：US20070106074A1

  公开（公告）日：2007-05-10

  Disclosed is a process for preparing a compound of formula A-N═C(D)(B), from a compound of formula A-N═C(E)(B) and a compound of formula D-M using an iron catalyst, where the process has is represented by Equation (I)

  揭示了一种使用铁催化剂，从化合物A-N═C（E）（B）和化合物D-M制备化合物A-N═C（D）（B）的过程，该过程由方程式（I）表示。
• NONCARDIOTOXIC PHARMACEUTICAL COMPOUNDS
  申请人：Barbeau, Donald L.

  公开号：EP1778252A2

  公开（公告）日：2007-05-02
• [EN] NONCARDIOTOXIC PHARMACEUTICAL COMPOUNDS<br/>[FR] COMPOSES PHARMACEUTIQUES NON CARDIOTOXIQUES
  申请人：BARBEAU DONALD L

  公开号：WO2006020573A2

  公开（公告）日：2006-02-23

  The present invention relates to novel noncardiotoxic compounds and pharmaceutical compositions useful in the treatment of a variety of disorders including the treatment of depression, allergies, psychoses, cancer and gastrointestinal disorders. In particular, the present invention describes pharmaceutical compositions that mitigate life-threatening arrhythmias such as torsade de pointes. Torsade de pointes is a particular cardiac problem associated with many therapeutic agents and has been implicated as a possible cause of sudden death, particularly in those individuals with a past history of disturbances of cardiac rhythm, myocardial infarction, congenital repolarization abnormalities and cardiac risk factors such as hyperlipidemia and age. This arrhythmia is a variant of paroxysmal ventricular tachycardia associated with a prolonged QTc interval or prominent U waves on the ECG. Torsade de pointes is potentially lethal because it can progress to ventricular fibrillation, life-threatening arrhythmias or precipitate sudden death.
• CN116854643
  申请人：——

  公开号：——

  公开（公告）日：——