2,5-anhydro-1-deoxy-1-(uracil-1'-yl)-6-((5''-guanidino)-1'',5''-dideoxy-2'',3''-dihydroxy-β-D-ribos-1''-yl)-D-glucitol | 1237748-09-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,5-anhydro-1-deoxy-1-(uracil-1'-yl)-6-((5''-guanidino)-1'',5''-dideoxy-2'',3''-dihydroxy-β-D-ribos-1''-yl)-D-glucitol
• 英文别名: 2-[[(2R,3S,4R,5R)-5-[[(2R,3S,4S,5S)-5-[(2,4-dioxopyrimidin-1-yl)methyl]-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxyoxolan-2-yl]methyl]guanidine
• CAS: 1237748-09-2
• 化学式: C₁₆H₂₅N₅O₉
• 分子量: 431.403
• InChiKey: QFAVQNSGVNOYJA-IPCBSVLMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.3
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  222
• 氢给体数：
  7
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  2,5-anhydro-1-deoxy-1-(3'-(N-tert-butyloxycarbonyl)uracil-1'-yl)-6-(5''-(N,N',N'',N''-tetra-(tert-butyloxycarbonyl)guanidino)-1'',5''-dideoxy-2'',3''-O-isopentylidene-β-D-ribos-1''-yl)-D-glucitol 在 水 、 三氟乙酸 作用下， 以60%的产率得到2,5-anhydro-1-deoxy-1-(uracil-1'-yl)-6-((5''-guanidino)-1'',5''-dideoxy-2'',3''-dihydroxy-β-D-ribos-1''-yl)-D-glucitol
  参考文献：
  名称：

  Bacterial transferase MraY inhibitors: Synthesis and biological evaluation

  摘要：

  New inhibitors of the bacterial transferase MraY are described. Their structure is based on an aminoribosyl-O-uridine like scaffold, readily obtained in two key steps. The amino group can be coupled with proline or guanylated. Alternatively, these amino, prolinyl or guanidinyl groups can be introduced through a triazole linker. Biological evaluation of these compounds on MraY from Bacillus subtilis revealed interesting inhibitory activity for both amino compounds. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2010.04.023

文献信息

• Bacterial transferase MraY inhibitors: Synthesis and biological evaluation
  作者：Delphine Lecerclé、Anthony Clouet、Bayan Al-Dabbagh、Muriel Crouvoisier、Ahmed Bouhss、Christine Gravier-Pelletier、Yves Le Merrer

  DOI：10.1016/j.bmc.2010.04.023

  日期：2010.6.15

  New inhibitors of the bacterial transferase MraY are described. Their structure is based on an aminoribosyl-O-uridine like scaffold, readily obtained in two key steps. The amino group can be coupled with proline or guanylated. Alternatively, these amino, prolinyl or guanidinyl groups can be introduced through a triazole linker. Biological evaluation of these compounds on MraY from Bacillus subtilis revealed interesting inhibitory activity for both amino compounds. (C) 2010 Published by Elsevier Ltd.