4-[2-(1H-imidazol-1-yl)ethoxy]-4-oxobutanoic acid | 87487-91-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-[2-(1H-imidazol-1-yl)ethoxy]-4-oxobutanoic acid
• 英文别名: 4-(2-imidazol-1-ylethoxy)-4-oxobutanoic acid
• CAS: 87487-91-0
• 化学式: C₉H₁₂N₂O₄
• 分子量: 212.205
• InChiKey: OKPNAGHEIRXPRC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  81.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  丁二酸酐 、 1-(2-羟乙基)咪唑 以 四氢呋喃 为溶剂， 反应 6.0h， 生成 4-[2-(1H-imidazol-1-yl)ethoxy]-4-oxobutanoic acid
  参考文献：
  名称：

  聚异丁烯-共-异戊二烯的溴化咪唑鎓衍生物：一类新的弹性体离聚物

  摘要：

  新的溴化咪唑鎓离聚物是通过卤化取代溴化聚异丁烯-异戊二烯（BIIR）和各种基于咪唑的亲核试剂而制备的。丁基咪唑（BuIm）通过BIIR中的烯丙基卤化物官能团进行N-烷基化可稳定地提供高产率的溴化咪唑鎓官能团。通过稀溶液粘度和固态流变学对所得可热成型离聚物的表征显示了离子对聚集在一系列离聚物组成范围内对材料性能的影响。通过BiIR与1,1'（1,4-丁二基）双（咪唑）和咪唑的无溶剂反应，扩大了BuIm烷基化的知识以生产热固性离聚物衍生物，其物理性质既来自共价网络又来自于离子对聚集体。

  DOI：

  10.1016/j.polymer.2011.10.021

文献信息

• Thermoset Ionomer Derivatives of Halogenated Polymers
  申请人：Parent J. Scott

  公开号：US20120148773A1

  公开（公告）日：2012-06-14

  Nucleophilic substitution reactions of halogenated polymers and cross-linking nucleophiles are used to produce thermoset ionomers. These cured ionomers are useful in adhesive, antimicrobial applications, as well as in polymer composites and polymer blends. Furthermore, these thermoset ionomers' ion pairs can bear reactive functionality, which provides access to further reactions that were unavailable using previous technology.

  卤代聚合物的亲核取代反应和交联亲核试剂可用于生产热固性离子聚合物。这些固化离子聚合物在粘合剂、抗微生物应用、聚合物复合材料和聚合物混合物方面非常有用。此外，这些热固性离子聚合物的离子对可以承载反应性功能，从而提供了使用先前技术无法实现的进一步反应的途径。
• COMBINING PH AND METABOLIC ACTIVITY IMAGING FOR RESPONSE ASSESSMENT IN IMMUNE THERAPY
  申请人：KONINKLIJKE PHILIPS N.V.

  公开号：US20200372653A1

  公开（公告）日：2020-11-26

  A computerized system for monitoring cancer therapy and a related method. The system comprises an input port (IN) for receiving two or more input images acquired of a subject, the two or more input images capable of recording metabolic activity and extracellular pH level. An evaluator (EVAL) of the system is configured to assess, based on the input images, i) a change over time in metabolic activity and ii) a change over time in extracellular pH level. The evaluator (EVAL) is further configured to establish, based on the assessment, an indication on whether or not there is a response to a cancer therapy in relation to a lesion of the subject or on whether the assessment is inconclusive. The indication is output through an output interface (OUT).
• [EN] THERMOSET LONOMER DERIVATIVES OF HALOGENATED POLYMERS<br/>[FR] DÉRIVÉS D'IONOMÈRE THERMODURCISSABLES DE POLYMÈRES HALOGÉNÉS
  申请人：UNIV KINGSTON

  公开号：WO2012075573A1

  公开（公告）日：2012-06-14

  Nucleophilic substitution reactions of halogenated polymers and cross-linking nucleophiles are used to produce thermoset ionomers. These cured ionomers are useful in adhesive, antimicrobial applications, as well as in polymer composites and polymer blends. Furthermore, these thermoset ionomers' ion pairs can bear reactive functionality, which provides access to further reactions that were unavailable using previous technology.