diphenyl(2,4-dimethoxy-6-pyrimidyl)phosphane | 1236194-07-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: diphenyl(2,4-dimethoxy-6-pyrimidyl)phosphane
• 英文别名: (2,6-Dimethoxypyrimidin-4-yl)-diphenylphosphane
• CAS: 1236194-07-2
• 化学式: C₁₈H₁₇N₂O₂P
• 分子量: 324.319
• InChiKey: NVVAWRMZKSECIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  44.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  diphenyl(2,4-dimethoxy-6-pyrimidyl)phosphane 在 水 、 双氧水 作用下， 反应 0.5h， 以57.2 mg的产率得到diphenyl(2,4-dimethoxy-6-pyrimidyl)phosphane oxide
  参考文献：
  名称：

  Short Access to 6-Substituted Pyrimidine Derivatives by the S_RN1 Mechanism. Synthesis of 6-Substituted Uracils through a One-Pot Procedure

  摘要：

  The synthesis of 6-substituted 2,4-dimethoxypyrimidines with different nucleophiles was accomplished with good to excellent yields (50-95%) through S(RN)1 reactions, starting from commercially available 6-chloro-2,4-dimethoxypyrimidine (1). Hydrolysis of these derivatives gave access to 6-substituted uracils with good yields and short times by the use of microwave irradiation. The preparation of uracils from 1 without the isolation of 2,4-dimethoxypyrimidine derivatives affords a rapid access to these compounds in good yields and excellent purity by avoiding an unnecessary step of purification.

  DOI：

  10.1021/jo101064e
• 作为产物：
  描述：

  6-氯-2,4-甲氧基嘧啶 、 三苯基膦 在 氨 、 sodium 作用下， 以 乙醇 、 叔丁醇 为溶剂， 反应 0.17h， 以57%的产率得到diphenyl(2,4-dimethoxy-6-pyrimidyl)phosphane
  参考文献：
  名称：

  Short Access to 6-Substituted Pyrimidine Derivatives by the S_RN1 Mechanism. Synthesis of 6-Substituted Uracils through a One-Pot Procedure

  摘要：

  The synthesis of 6-substituted 2,4-dimethoxypyrimidines with different nucleophiles was accomplished with good to excellent yields (50-95%) through S(RN)1 reactions, starting from commercially available 6-chloro-2,4-dimethoxypyrimidine (1). Hydrolysis of these derivatives gave access to 6-substituted uracils with good yields and short times by the use of microwave irradiation. The preparation of uracils from 1 without the isolation of 2,4-dimethoxypyrimidine derivatives affords a rapid access to these compounds in good yields and excellent purity by avoiding an unnecessary step of purification.

  DOI：

  10.1021/jo101064e

文献信息

• Short Access to 6-Substituted Pyrimidine Derivatives by the S_RN1 Mechanism. Synthesis of 6-Substituted Uracils through a One-Pot Procedure
  作者：Javier I. Bardagí、Roberto A. Rossi

  DOI：10.1021/jo101064e

  日期：2010.8.6

  The synthesis of 6-substituted 2,4-dimethoxypyrimidines with different nucleophiles was accomplished with good to excellent yields (50-95%) through S(RN)1 reactions, starting from commercially available 6-chloro-2,4-dimethoxypyrimidine (1). Hydrolysis of these derivatives gave access to 6-substituted uracils with good yields and short times by the use of microwave irradiation. The preparation of uracils from 1 without the isolation of 2,4-dimethoxypyrimidine derivatives affords a rapid access to these compounds in good yields and excellent purity by avoiding an unnecessary step of purification.