N-Boc-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactic acid | 157567-65-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Boc-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactic acid
• 英文别名: (2R)-2-[(2S)-4-methyl-2-[methyl-[(2R)-2-[(2S)-4-methyl-2-[methyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]pentanoyl]oxypropanoyl]amino]pentanoyl]oxy-3-phenylpropanoic acid
• CAS: 157567-65-2
• 化学式: C₃₁H₄₈N₂O₉
• 分子量: 592.73
• InChiKey: ZJXWSUNFVKGSAF-DDKRZIBASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.31
• 重原子数：
  42.0
• 可旋转键数：
  14.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  139.75
• 氢给体数：
  1.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  N-Boc-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactic acid 在 palladium on activated charcoal 4-二甲氨基吡啶 、 氢气 、 双(2-氧代-3-恶唑烷基)次磷酰氯 、 N,N'-二环己基碳二亚胺 、 三氟乙酸 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 25.0 ℃ 、344.74 kPa 条件下， 反应 57.0h， 生成 (2S,5R,8S,11R,14S,17R,20S,23R)-5,17-Dibenzyl-2,8,14,20-tetraisobutyl-7,11,13,19-tetramethyl-4,10,16,22-tetraoxa-1,7,13,19-tetraaza-bicyclo[21.3.1]heptacosan-3,6,9,12,15,18,21,27-octaone
  参考文献：
  名称：

  Restricted Conformation Analogues of an Anthelmintic Cyclodepsipeptide

  摘要：

  Six analogues of the anthelmintic cyclodepsipeptide PF1022A were prepared, each containing a small ring fused to the macrocycle to restrict the number of conformations the larger ring can adopt. It was anticipated that such conformational changes could lead to enhanced biological activity and selectivity. The analogues form two series of three members each. In one series, a carbon-based molecular bridge joins the methyl of a leucine residue with the methyl of its closest lactic acid residue to form five-, six-, and seven-membered lactam rings. In the second series, a leucine residue is replaced with five-, six-, and seven-membered nitrogen heterocycles. Decreasing the size of the small ring in the lactam. series increasingly distorts the macrocycle and consistently decreases activity relative to PF1022A. In the leucine series, a similar trend is observed. Molecular modeling of PF1022A along with the analogues described herein suggests that the ability to exist in a highly symmetrical conformational state is a necessary condition for biological activity.

  DOI：

  10.1021/jm020482k
• 作为产物：
  描述：

  N-t-butoxycarbonyl-N-methyl-L-leucine 在 palladium on activated charcoal N-甲基吗啉 、 氢气 、 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 甲醇 、 乙醚 为溶剂， 生成 N-Boc-N-methyl-L-leucyl-D-lactyl-N-methyl-L-leucyl-3-phenyl-D-lactic acid
  参考文献：
  名称：

  Ohyama, Makoto; Iinuma, Katsuharu; Isogai, Akira, Bioscience, Biotechnology and Biochemistry, 1994, vol. 58, # 6, p. 1193 - 1194

  摘要：

  DOI：

文献信息

• Epsilon-lactam analogs of the anthelmintic cyclodepsipeptide PF1022A
  作者：Fred E. Dutton、Byung H. Lee

  DOI：10.1016/s0040-4039(98)01075-2

  日期：1998.7

  Conformationally restricted analogs of the anthelmintic cyclodepsipeptide PF1022A 1 were prepared by fusing a seven-membered lactam ring onto the macrocycle. Following the preparation of cyclodepsipeptide (CDP) 2 by classical chemical methods, CDPs 2 and 3 were synthesized using solid phase methodology involving cyclization-cleavage from an oxime resin. (C) 1998 Elsevier Science Ltd; All rights reserved.