2-(4-Chlorophenyl)-7-ethoxy-3-phenyl-2,3-dihydrochromen-4-one | 1229005-62-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-(4-Chlorophenyl)-7-ethoxy-3-phenyl-2,3-dihydrochromen-4-one
• CAS: 1229005-62-2
• 化学式: C₂₃H₁₉ClO₃
• 分子量: 378.855
• InChiKey: RRFDHFLTAVQSBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  benzyl-2-hydroxy-4-ethoxyphenylketone 、 4-氯苯甲醛 在 二乙胺 作用下， 反应 0.43h， 以80%的产率得到2-(4-Chlorophenyl)-7-ethoxy-3-phenyl-2,3-dihydrochromen-4-one
  参考文献：
  名称：

  Synthesis, anticancer and antioxidant activities of 7-methoxyisoflavanone and 2,3-diarylchromanones

  摘要：

  A convenient, fast and high yielding method for the preparation of 7-methoxyisoflavanone and 2,3-diarylchromanones has been developed by the condensation of benzyl-2-hydroxy-4-alkoxyphenylketone with arylaldehyde/paraformaldehyde in presence of diethylamine, assisted by microwave activation. All the synthesized compounds were screened for anticancer as well as antioxidant activities. Among the nine compounds, 7-methoxyisoflavanone 7 and diarylchromanone 6c shows potential anticancer activity and diarylchromanone 6b has potential antioxidant activity. Compound 6h possesses anticancer and antioxidant activity at the same concentration.

  DOI：

  10.1016/j.ejmech.2010.02.028

文献信息

• Synthesis, anticancer and antioxidant activities of 7-methoxyisoflavanone and 2,3-diarylchromanones
  作者：Kanagasabai Kanagalakshmi、Mariappan Premanathan、Ragunathan Priyanka、Balasubramanian Hemalatha、Arumugasamy Vanangamudi

  DOI：10.1016/j.ejmech.2010.02.028

  日期：2010.6

  A convenient, fast and high yielding method for the preparation of 7-methoxyisoflavanone and 2,3-diarylchromanones has been developed by the condensation of benzyl-2-hydroxy-4-alkoxyphenylketone with arylaldehyde/paraformaldehyde in presence of diethylamine, assisted by microwave activation. All the synthesized compounds were screened for anticancer as well as antioxidant activities. Among the nine compounds, 7-methoxyisoflavanone 7 and diarylchromanone 6c shows potential anticancer activity and diarylchromanone 6b has potential antioxidant activity. Compound 6h possesses anticancer and antioxidant activity at the same concentration.