Indolin-sulfonsaeure-(5)-diethylamid | 92788-94-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: Indolin-sulfonsaeure-(5)-diethylamid
• 英文别名: indole-5-sulfonic acid diethylamide；N,N-diethyl-1H-indole-5-sulfonamide
• CAS: 92788-94-8
• 化学式: C₁₂H₁₆N₂O₂S
• 分子量: 252.337
• InChiKey: FQCPFGGUUOOEDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  61.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• EP2203160A1
  申请人：——

  公开号：EP2203160A1

  公开（公告）日：2010-07-07
• [EN] PHARMACOLOGICAL ADJUNCTIVE TREATMENT ASSOCIATED WITH GLAUCOMA FILTRATION SURGERY<br/>[FR] TRAITEMENT PHARMACOLOGIQUE D'APPOINT ASSOCIÉ À UNE CHIRURGIE FILTRANTE DU GLAUCOME
  申请人：BAUSCH & LOMB

  公开号：WO2009042377A1

  公开（公告）日：2009-04-02

  A composition for controlling or preventing progression of glaucoma comprises a material that reduces or inhibits production of a TGF-β isoform or a chemokine or cytokine that stimulates expression of a TGF-β isoform. The material can comprise a dissociated glucocorticoid receptor agonist ('DIGRA'), a prodrug thereof, a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable ester thereof. The composition can further comprise an antagonist to TGF-β. It is administered to a patient who has undergone glaucoma filtration surgery to ensure a functioning filtering bleb following such surgery.