CP-γDLen-C2K-DMA | 1347052-18-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: CP-γDLen-C2K-DMA
• 英文别名: 2-[2,2-bis[5-[2-[[2-[(2-pentylcyclopropyl)methyl]cyclopropyl]methyl]cyclopropyl]pentyl]-1,3-dioxolan-4-yl]-N,N-dimethylethanamine
• CAS: 1347052-18-9
• 化学式: C₄₉H₈₇NO₂
• 分子量: 722.235
• InChiKey: GGNRYPQNTOXRBS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  17.4
• 重原子数：
  52
• 可旋转键数：
  31
• 环数：
  7.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-[2,2-bis[(6Z,9Z,12Z)-octadeca-6,9,12-trienyl]-1,3-dioxolan-4-yl]ethyl methanesulfonate 在 Dimethylzinc 作用下， 以 甲醇 、 正己烷 、 二氯甲烷 、 异丙醇 为溶剂， 反应 73.0h， 生成 CP-γDLen-C2K-DMA
  参考文献：
  名称：

  [EN] NOVEL CYCLIC CATIONIC LIPIDS AND METHODS OF USE
  [FR] NOUVEAUX LIPIDES CATIONIQUES CYCLIQUES ET PROCÉDÉS D'UTILISATION

  摘要：

  本发明提供了用于将治疗剂传递至细胞的组合物和方法。具体包括新型阳离子脂质和核酸-脂质颗粒，能够有效地封装核酸并有效地将封装的核酸传递至体内细胞。本发明的组合物非常强效，因此能够以相对较低的剂量有效地降低特定靶蛋白的表达。此外，与先前已知的组合物和方法相比，本发明的组合物和方法毒性较低，提供更大的治疗指数。

  公开号：

  WO2011141704A1

文献信息

• COMPOSITIONS AND METHODS FOR SILENCING APOLIPOPROTEIN B
  申请人：Heyes James

  公开号：US20130123339A1

  公开（公告）日：2013-05-16

  The present invention provides compositions and methods for the delivery of interfering RNAs such as siRNAs that silence APOB expression in cells such as liver cells. In particular, the nucleic acid-lipid particles provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells such as liver cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of APOB at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

  本发明提供了一种用于传递干扰RNA（如siRNA）的组合物和方法，用于在细胞中（如肝细胞）沉默APOB表达。具体来说，核酸-脂质颗粒能够有效地封装核酸，并有效地将封装的核酸传递给体内的细胞，如肝细胞。本发明的组合物非常有效，因此可以在相对较低的剂量下有效地降低APOB的表达。此外，与先前已知的技术相比，本发明的组合物和方法毒性较低，并且提供了更大的治疗指数。
• NOVEL CYCLIC CATIONIC LIPIDS AND METHODS OF USE
  申请人：Heyes James

  公开号：US20130116307A1

  公开（公告）日：2013-05-09

  The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

  本发明提供了传递治疗剂到细胞的组合物和方法。特别地，这些包括新型阳离子脂质和核酸-脂质颗粒，它们提供了核酸的高效封装和封装的核酸在体内的高效传递到细胞。本发明的组合物非常有效，因此可以在相对较低的剂量下有效地击打特定的靶蛋白。此外，本发明的组合物和方法比先前在艺术上已知的组合物和方法毒性更小，并提供更大的治疗指数。
• US8455455B1
  申请人：——

  公开号：US8455455B1

  公开（公告）日：2013-06-04
• US8865675B2
  申请人：——

  公开号：US8865675B2

  公开（公告）日：2014-10-21
• [EN] COMPOSITIONS AND METHODS FOR SILENCING APOLIPOPROTEIN B<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR RÉDUIRE AU SILENCE L'APOLIPOPROTÉINE B
  申请人：PROTIVA BIOTHERAPEUTICS INC

  公开号：WO2011141703A1

  公开（公告）日：2011-11-17

  The present invention provides compositions and methods for the delivery of interfering RNAs such as siRNAs that silence APOB expression in cells such as liver cells. In particular, the nucleic acid-lipid particles provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells such as liver cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of APOB at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.