3-[5-(Carbazol-9-ylmethyl)-1,3,4-thiadiazol-2-yl]-2-(2,4-dihydroxyphenyl)-1,3-thiazolidin-4-one | 1234551-29-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-[5-(Carbazol-9-ylmethyl)-1,3,4-thiadiazol-2-yl]-2-(2,4-dihydroxyphenyl)-1,3-thiazolidin-4-one
• CAS: 1234551-29-1
• 化学式: C₂₄H₁₈N₄O₃S₂
• 分子量: 474.564
• InChiKey: HPSADHVHLFNXND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  145
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  、 巯基乙酸 在 zinc(II) chloride 作用下， 以 甲醇 为溶剂， 反应 106.0h， 以85%的产率得到3-[5-(Carbazol-9-ylmethyl)-1,3,4-thiadiazol-2-yl]-2-(2,4-dihydroxyphenyl)-1,3-thiazolidin-4-one
  参考文献：
  名称：

  Synthesis and antipsychotic and anticonvulsant activity of some new substituted oxa/thiadiazolylazetidinonyl/thiazolidinonylcarbazoles

  摘要：

  A novel substituted oxa/thiadiazolylazetidinonyl/thiazolidinonylcarbazoles (4a-j), (5a-j) and (6a-j) were synthesized and screened for their antipsychotic and anticonvulsant activities. It is concluded from the results compound 6j showed promising antipsychotic as well as anticonvulsant activity. (C) 2010 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2010.02.060

文献信息

• Synthesis and antipsychotic and anticonvulsant activity of some new substituted oxa/thiadiazolylazetidinonyl/thiazolidinonylcarbazoles
  作者：Hemlata Kaur、Sunil Kumar、Pinki Vishwakarma、Monica Sharma、K.K. Saxena、Ashok Kumar

  DOI：10.1016/j.ejmech.2010.02.060

  日期：2010.7

  A novel substituted oxa/thiadiazolylazetidinonyl/thiazolidinonylcarbazoles (4a-j), (5a-j) and (6a-j) were synthesized and screened for their antipsychotic and anticonvulsant activities. It is concluded from the results compound 6j showed promising antipsychotic as well as anticonvulsant activity. (C) 2010 Elsevier Masson SAS. All rights reserved.