(6R)-6-(2,6-diamino-purin-9-yl)-3,6-anhydro-1-deoxy-L-altritol | 109962-64-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: (6R)-6-(2,6-diamino-purin-9-yl)-3,6-anhydro-1-deoxy-L-altritol
• 英文别名: (6R)-6-(2,6-Diamino-purin-9-yl)-3,6-anhydro-1-desoxy-L-altrit；(2R,3R,4S,5R)-2-(2,6-diaminopurin-9-yl)-5-[(1S)-1-hydroxyethyl]oxolane-3,4-diol
• CAS: 109962-64-3
• 化学式: C₁₁H₁₆N₆O₄
• 分子量: 296.286
• InChiKey: YQEGUSIVBIKRPV-MOQPINPBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  166
• 氢给体数：
  5
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 、 alkaline earth salt of/the/ methylsulfuric acid 生成 (6R)-6-(2,6-diamino-purin-9-yl)-3,6-anhydro-1-deoxy-L-altritol
  参考文献：
  名称：

  Potential Anticancer Agents.¹ VIII. Synthesis of Nucleosides Derived from L-Talofuranose

  摘要：

  DOI：

  10.1021/ja01554a046

文献信息

• SUBSTITUTED NUCLEOTIDE ANALOGS
  申请人：Beigelman Leonid

  公开号：US20120070411A1

  公开（公告）日：2012-03-22

  Disclosed herein are phosphoroamidate nucleotide analogs, methods of synthesizing phosphoroamidate nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with the phosphoroamidate nucleotide analogs.

  本文揭示了磷酰胺核苷类似物、合成磷酰胺核苷类似物的方法以及使用磷酰胺核苷类似物治疗病毒感染、癌症和/或寄生虫病等疾病和/或病况的方法。
• [EN] SUBSTITUTED NUCLEOTIDE ANALOGS<br/>[FR] ANALOGUES DE NUCLÉOTIDES SUBSTITUÉS
  申请人：ALIOS BIOPHARMA INC

  公开号：WO2012040126A1

  公开（公告）日：2012-03-29

  Disclosed herein are phosphoroamidate nucleotide analogs, methods of synthesizing phosphoroamidate nucleotide analogs and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with the phosphoroamidate nucleotide analogs.